Tomberg T A, Miagi M A, Rekand T E, Alilender M V, Iaanson Ia Kh
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(9):34-8.
The authors have studied the regional volume cerebral blood flow (RVCBF) in 25 patients with acute cerebral infarction before and after the intravenous administration of 5-7.5 mg of isoptin and carried out quantitative frequency analysis of the EEG in 20 patients prior to and following the administration of 5 mg of finoptin. It has been revealed that isoptin augments the RVCBF in the infarcted zone, particularly when patients with extensive infarction, edema and atrophy of the cerebral tissue (according to findings of computer-aided tomography) have low baseline levels of the RVCF and somewhat decreases the blood flow in intact zones. The administration of finoptin tended to normalize the EEG, particularly in the infarcted area in patients with a severe clinical picture of infarction. Calcium antagonists of the verapamil type exert a favourable effect on perfusion and bioelectrical activity of the brain; as a result their use is indicated in the patients with acute cerebral infarction.
作者对25例急性脑梗死患者静脉注射5 - 7.5毫克异搏定前后的局部脑血流量（RVCBF）进行了研究，并对20例患者在注射5毫克氟桂利嗪前后的脑电图进行了定量频率分析。结果显示，异搏定可增加梗死区域的RVCBF，尤其是在脑组织广泛梗死、水肿和萎缩（根据计算机断层扫描结果）且RVCF基线水平较低的患者中，同时会使正常区域的血流量略有减少。氟桂利嗪的使用倾向于使脑电图正常化，特别是在梗死临床表现严重的患者的梗死区域。维拉帕米型钙拮抗剂对脑灌注和生物电活动有有利影响；因此，在急性脑梗死患者中使用此类药物是有指征的。
