Poznan University of Medical Sciences, Department of Internal Medicine and Diabetology, 60-834 Poznan, Poland.
Int J Mol Sci. 2020 Apr 19;21(8):2852. doi: 10.3390/ijms21082852.
Type 1 diabetes mellitus is a disease involving changes to energy metabolism. Chronic hyperglycemia is a major cause of diabetes complications. Hyperglycemia induces mechanisms that generate the excessive production of reactive oxygen species, leading to the development of oxidative stress. Studies with animal models have indicated the involvement of mitochondrial dysfunction in the pathogenesis of diabetic cardiomyopathy. In the current review, we aimed to collect scientific reports linking disorders in mitochondrial functioning with the development of diabetic cardiomyopathy in type 1 diabetes mellitus. We also aimed to present therapeutic approaches counteracting the development of mitochondrial dysfunction and diabetic cardiomyopathy in type 1 diabetes mellitus.
1 型糖尿病是一种涉及能量代谢变化的疾病。慢性高血糖是糖尿病并发症的主要原因。高血糖诱导产生活性氧的机制，导致氧化应激的发展。动物模型的研究表明，线粒体功能障碍与 1 型糖尿病性心肌病的发病机制有关。在本次综述中，我们旨在收集将线粒体功能障碍与 1 型糖尿病性心肌病的发展联系起来的科学报告。我们还旨在介绍对抗 1 型糖尿病中线粒体功能障碍和糖尿病性心肌病发展的治疗方法。
