Yang Yanxiao, Jiang Qinhong, Peng Min, Zhou Ziyi, Du Xiangge, Yin Meizhen, Shen Jie, Yan Shuo
Department of Plant Biosecurity and MOA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University, Beijing 100193, China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Nanomaterials (Basel). 2022 Apr 23;12(9):1445. doi: 10.3390/nano12091445.
The unscientific application of synthesized/botanical pesticides has not only brought the resistance of plant pathogens and pests, but also led to serious environmental pollution. In recent years, various nano-delivery systems have been used for the development of environmental-friendly pesticides with improved efficacy. Herein, the current study constructed an efficient avermectin B1a (AVM) nano-delivery system based on a star polyamine (SPc) and focused on the characterization and bioactivity of SPc-loaded AVM at various mass ratios. The hydroxyl groups of AVM could assemble with carbonyl groups of SPc through hydrogen bond and van der Waals forces, and the self-assembly of AVM and SPc formed nearly spherical particles of AVM/SPc complex with nanoscale size. The contact angle of SPc-loaded AVM decreased with the increasing mass ratio of SPc, revealing the easier distribution and spreading of the AVM/SPc complex. Furthermore, the stomach and contact toxicity of AVM/SPc complex also increased along with the increasing SPc mass ratio, which could be attributed to the enhanced systemic transportation in plants, enlarged contact area to insect pests and stronger permeability across the insect cuticle. The current study provides an efficient nano-delivery system for increasing stomach and contact toxicity of pesticides with wide applications in the agricultural field.
合成/植物源农药的不科学施用不仅导致了植物病原体和害虫的抗性，还造成了严重的环境污染。近年来，各种纳米递送系统已被用于开发具有更高功效的环保型农药。在此，本研究构建了一种基于星型多胺（SPc）的高效阿维菌素B1a（AVM）纳米递送系统，并重点研究了不同质量比下负载SPc的AVM的表征和生物活性。AVM的羟基可通过氢键和范德华力与SPc的羰基组装在一起，AVM与SPc的自组装形成了具有纳米级尺寸的近似球形的AVM/SPc复合物颗粒。负载SPc的AVM的接触角随SPc质量比的增加而降低，这表明AVM/SPc复合物更容易分布和铺展。此外，AVM/SPc复合物的胃毒和触杀毒性也随着SPc质量比的增加而增加，这可能归因于其在植物体内增强的系统运输、与害虫接触面积的扩大以及对昆虫表皮更强的渗透性。本研究提供了一种高效的纳米递送系统，可提高农药的胃毒和触杀毒性，在农业领域具有广泛的应用。
