Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3, Canada.
Vet Clin North Am Food Anim Pract. 2020 Jul;36(2):269-278. doi: 10.1016/j.cvfa.2020.02.002. Epub 2020 Apr 21.
Mycoplasma bovis is an important component of the bovine respiratory disease complex and recent reports identified that other species are also affected by M bovis. Control of the disease caused by M bovis has been unsuccessful owing to many factors, including the capacity of M bovis to evade and modulate the immune system of the host; the lack of known virulence factors; the absence of a cell wall, which renders antibiotics targeting cell-wall synthesis unusable; and the failure of vaccines to control disease on the field. The current knowledge on virulence and pathogenesis is presented in this review.
牛支原体是牛呼吸道疾病复合体的重要组成部分，最近的报告表明，其他物种也受到牛支原体的影响。由于多种因素，包括牛支原体逃避和调节宿主免疫系统的能力、缺乏已知的毒力因子、缺乏细胞壁，使针对细胞壁合成的抗生素无法使用，以及疫苗未能控制田间疾病，导致牛支原体引起的疾病的控制一直不成功。本文综述了目前关于毒力和发病机制的知识。
