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First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA.美国首例人传人严重急性呼吸综合征冠状病毒 2 型(SARS-CoV-2)。
Lancet. 2020 Apr 4;395(10230):1137-1144. doi: 10.1016/S0140-6736(20)30607-3. Epub 2020 Mar 13.
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Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures.新型冠状病毒肺炎(COVID-19)具有独特的流行病学和临床特征,提示应采取特殊的控制措施。
J Med Virol. 2020 Jun;92(6):568-576. doi: 10.1002/jmv.25748. Epub 2020 Mar 29.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.《武汉 2019 年新型冠状病毒感染的肺炎 138 例住院患者临床特征分析》
JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585.
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Chest CT Findings in 2019 Novel Coronavirus (2019-nCoV) Infections from Wuhan, China: Key Points for the Radiologist.中国武汉2019新型冠状病毒(2019-nCoV)感染的胸部CT表现:放射科医生的要点
Radiology. 2020 Apr;295(1):16-17. doi: 10.1148/radiol.2020200241. Epub 2020 Feb 4.
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.新冠病毒的基因组特征和流行病学:对病毒起源和受体结合的影响。
Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.新型冠状病毒感染肺炎在中国武汉的早期传播动力学。
N Engl J Med. 2020 Mar 26;382(13):1199-1207. doi: 10.1056/NEJMoa2001316. Epub 2020 Jan 29.
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Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan.从武汉旅行回来后出现非典型肺炎症状的患者身上分离出的 2019 年新型人致病冠状病毒的基因组特征。
Emerg Microbes Infect. 2020 Jan 28;9(1):221-236. doi: 10.1080/22221751.2020.1719902. eCollection 2020.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
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Coronaviruses: an overview of their replication and pathogenesis.冠状病毒:其复制与发病机制概述
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冠状病毒(COVID-19):临床特征、诊断与治疗综述

Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment.

作者信息

Hassan Syed Adeel, Sheikh Fahad N, Jamal Somia, Ezeh Jude K, Akhtar Ali

机构信息

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Pathology, Sahiwal Medical College, Sahiwal, PAK.

出版信息

Cureus. 2020 Mar 21;12(3):e7355. doi: 10.7759/cureus.7355.

DOI:10.7759/cureus.7355
PMID:32328367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7170025/
Abstract

Coronavirus (COVID-19) is an enveloped RNA virus that is diversely found in humans and wildlife. A total of six species have been identified to cause disease in humans. They are known to infect the neurological, respiratory, enteric, and hepatic systems. The past few decades have seen endemic outbreaks in the form of Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome related coronavirus (SARS-CoV). Yet again, we see the emergence of another outbreak due to a new strain called the SARS-CoV-2 virus. The most recent outbreak initially presented as pneumonia of unknown etiology in a cluster of patients in Wuhan, China. The epicenter of infection was linked to seafood and exotic animal wholesale markets in the city. SARS-CoV-2 is highly contagious and has resulted in a rapid pandemic of COVID-19. As the number of cases continues to rise, it is clear that these viruses pose a threat to public health. This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. It will also provide a means to raise awareness among primary and secondary healthcare providers during the current pandemic. Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling of patients worldwide.

摘要

冠状病毒(COVID-19)是一种包膜RNA病毒,在人类和野生动物中均有发现。已鉴定出总共六种可导致人类疾病的病毒。已知它们会感染神经、呼吸、肠道和肝脏系统。在过去几十年中,出现了中东呼吸综合征冠状病毒(MERS-CoV)和严重急性呼吸综合征相关冠状病毒(SARS-CoV)形式的地方性疫情。现在,我们又看到了由一种名为SARS-CoV-2病毒的新毒株引发的另一场疫情。最近的疫情最初在中国武汉一群患者中表现为病因不明的肺炎。感染源与该市的海鲜和 exotic 动物批发市场有关。SARS-CoV-2具有高度传染性,已导致COVID-19迅速大流行。随着病例数量持续上升,显然这些病毒对公众健康构成威胁。本综述将介绍冠状病毒的总体概况,并描述COVID-19患者的临床特征、评估和治疗。它还将提供一种在当前大流行期间提高初级和二级医疗保健提供者认识的方法。此外,我们的综述侧重于全球范围内有效管理、预防和咨询患者的最新临床信息。

注

原文中“exotic”疑为“exotic”拼写错误,正确拼写应为“exotic”,意为“外来的” ,但按照要求未对原文进行修改,直接翻译。