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冠状病毒(COVID-19):临床特征、诊断与治疗综述

Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment.

作者信息

Hassan Syed Adeel, Sheikh Fahad N, Jamal Somia, Ezeh Jude K, Akhtar Ali

机构信息

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Pathology, Sahiwal Medical College, Sahiwal, PAK.

出版信息

Cureus. 2020 Mar 21;12(3):e7355. doi: 10.7759/cureus.7355.

Abstract

Coronavirus (COVID-19) is an enveloped RNA virus that is diversely found in humans and wildlife. A total of six species have been identified to cause disease in humans. They are known to infect the neurological, respiratory, enteric, and hepatic systems. The past few decades have seen endemic outbreaks in the form of Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome related coronavirus (SARS-CoV). Yet again, we see the emergence of another outbreak due to a new strain called the SARS-CoV-2 virus. The most recent outbreak initially presented as pneumonia of unknown etiology in a cluster of patients in Wuhan, China. The epicenter of infection was linked to seafood and exotic animal wholesale markets in the city. SARS-CoV-2 is highly contagious and has resulted in a rapid pandemic of COVID-19. As the number of cases continues to rise, it is clear that these viruses pose a threat to public health. This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. It will also provide a means to raise awareness among primary and secondary healthcare providers during the current pandemic. Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling of patients worldwide.

摘要

冠状病毒(COVID-19)是一种包膜RNA病毒,在人类和野生动物中均有发现。已鉴定出总共六种可导致人类疾病的病毒。已知它们会感染神经、呼吸、肠道和肝脏系统。在过去几十年中,出现了中东呼吸综合征冠状病毒(MERS-CoV)和严重急性呼吸综合征相关冠状病毒(SARS-CoV)形式的地方性疫情。现在,我们又看到了由一种名为SARS-CoV-2病毒的新毒株引发的另一场疫情。最近的疫情最初在中国武汉一群患者中表现为病因不明的肺炎。感染源与该市的海鲜和 exotic 动物批发市场有关。SARS-CoV-2具有高度传染性,已导致COVID-19迅速大流行。随着病例数量持续上升,显然这些病毒对公众健康构成威胁。本综述将介绍冠状病毒的总体概况,并描述COVID-19患者的临床特征、评估和治疗。它还将提供一种在当前大流行期间提高初级和二级医疗保健提供者认识的方法。此外,我们的综述侧重于全球范围内有效管理、预防和咨询患者的最新临床信息。

原文中“exotic”疑为“exotic”拼写错误,正确拼写应为“exotic”,意为“外来的” ,但按照要求未对原文进行修改,直接翻译。

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