糖尿病肾病的动物模型和肾脏生物标志物。
Animal Models and Renal Biomarkers of Diabetic Nephropathy.
机构信息
Institute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain.
Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Spain.
出版信息
Adv Exp Med Biol. 2021;1307:521-551. doi: 10.1007/5584_2020_527.
Diabetes mellitus (DM) is the first cause of end stage chronic kidney disease (CKD). Animal models of the disease can shed light on the pathogenesis of the diabetic nephropathy (DN) and novel and earlier biomarkers of the condition may help to improve diagnosis and prognosis. This review summarizes the most important features of animal models used in the study of DN and updates the most recent progress in biomarker research.
糖尿病（DM）是终末期慢性肾脏病（CKD）的首要病因。该疾病的动物模型可以揭示糖尿病肾病（DN）的发病机制，而新型和更早的疾病生物标志物可能有助于改善诊断和预后。本文综述了用于研究 DN 的动物模型的最重要特征，并更新了生物标志物研究的最新进展。
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