Gupta Sandeep, Gupta Chandan Kumar, Bk Shyam, Gupta Nupur
Department of General Practice and Emergency Medicine, Gandaki Medical College and Teaching Hospital, Pokhara, Nepal.
Murarilal Gupta Memorial Hospital, Salampur, UP, India.
JNMA J Nepal Med Assoc. 2019 Sep-Oct;57(219):327-330. doi: 10.31729/jnma.4618.
Prevention of Human Immunodeficiency Virus infection is a high priority for the government of Nepal, so the government has been scaling up Anti Retroviral Therapy centers throughout the country. The objective of our study was to find out the prevalence of people living with Human Immunodeficiency Virus infection on Anti Retroviral Therapy service.
This descriptive cross-sectional study was done in Lamjung district hospital, from May 2017 till August 2017 after taking ethical clearance from the institutional review committee. The study was done in 96 patients and convenience sampling was done. The data collected was entered in Microsoft Excel and analyzed in Statistical Packages for Social Sciences version 17.0, point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.
Out of the total 109 patients enrolled at the hospital, 85 (78%) were on ongoing Anti Retroviral Therapy. The predominant age group among patients using Anti Retroviral Therapy was 25-34 years 27 (31.7%) and the five most common clinical manifestation/opportunistic infections were fever 40 (47.1%), diarrhea 34 (40%), fatigue/generalized weakness 32 (37.6%), loss of appetite 25 (29.4%) and headache 18 (21.2%) among them. Out of total patients, 14 (12.8%) of our patients were under 14 years of age. We found 71 (83.6%) of the patients continued the original first-line regimen and in 14 (16.5%) one or two drugs were substituted in the original regimen.
Our study showed a similar prevalence of people living with Human Immunodeficiency Virus infection on Anti Retroviral Therapy service with the other studies done within Nepal.
预防人类免疫缺陷病毒感染是尼泊尔政府的一项高度优先事项,因此政府一直在全国范围内扩大抗逆转录病毒治疗中心。我们研究的目的是找出接受抗逆转录病毒治疗服务的人类免疫缺陷病毒感染者的患病率。
这项描述性横断面研究于2017年5月至2017年8月在拉姆琼地区医院进行,此前已获得机构审查委员会的伦理批准。该研究对96名患者进行,采用便利抽样。收集的数据录入Microsoft Excel,并在社会科学统计软件包第17.0版中进行分析,计算95%置信区间的点估计值以及二元数据的频率和比例。
在该医院登记的109名患者中,85名(78%)正在接受抗逆转录病毒治疗。使用抗逆转录病毒治疗的患者中,主要年龄组为25 - 34岁,有27名(31.7%),其中五种最常见的临床表现/机会性感染为发热40名(47.1%)、腹泻34名(40%)、疲劳/全身无力32名(37.6%)、食欲不振25名(29.4%)和头痛18名(21.2%)。在所有患者中,14名(12.8%)患者年龄在14岁以下。我们发现71名(83.6%)患者继续使用原来的一线治疗方案,14名(16.5%)患者在原来的治疗方案中替换了一两种药物。
我们的研究显示,在接受抗逆转录病毒治疗服务的人类免疫缺陷病毒感染者患病率方面,与尼泊尔境内进行 的其他研究相似。