Center for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Human Genetics at Lung Biology Center, University of California San Francisco, San Francisco, California, USA.
Am J Hum Biol. 2020 Nov;32(6):e23426. doi: 10.1002/ajhb.23426. Epub 2020 Apr 24.
Hispanic populations typically show a high prevalence of dyslipidemias, especially of low high-density lipoproteins (HDLs) or HDL cholesterol. Highly admixed populations are ideal groups to clarify the role of genetic ancestry on HDL concentrations, isolating it from that of other factors. The objective of this study was to estimate the association between Native American genetic ancestry and HDL-cholesterol levels independent of socioeconomic factors in a representative sample of the Mexican population.
We used data from the Mexican National Health Survey 2000, analyzing 1647 subjects from whom stored DNA samples and HDL measurements were available. To estimate proportional genetic ancestry (Native American, African, and European), we used a 107 genetic ancestry informative marker panel with the software STRUCTURE. To estimate the association between genetic ancestry and low HDL levels, we fitted logistic regression models with the percentage of Native American genetic ancestry, in quartiles, as the main predictor.
Mean HDL levels were 38.9 mg/dL, with 62% of subjects having levels below 40 mg/dL. Participants had on average 53.6% Native American, 39% European, and 7.3% African genetic ancestry. Those in the fourth quartile of Native American genetic ancestry had 35% higher odds of having low HDL-cholesterol relative to those in the first quartile (odds ratio, 1.35; 95% confidence interval, 0.99-1.81) after adjustment for socioeconomic level and other covariates, although the association is clearly nonlinear.
Native American genetic ancestry seems to play a small but distinct role in the development of low HDL cholesterol levels.
西班牙裔人群通常表现出较高的血脂异常发生率，尤其是低高密度脂蛋白（HDL）或 HDL 胆固醇。高度混合人群是澄清遗传背景对 HDL 浓度影响的理想群体，使其与其他因素分离。本研究的目的是在墨西哥人群的代表性样本中，独立于社会经济因素，估计美洲原住民遗传背景与 HDL-胆固醇水平之间的关联。
我们使用了 2000 年墨西哥国家健康调查的数据，分析了 1647 名可提供储存 DNA 样本和 HDL 测量值的受试者。为了估计比例遗传背景（美洲原住民、非洲和欧洲），我们使用了带有 STRUCTURE 软件的 107 个遗传背景信息标记面板。为了估计遗传背景与低 HDL 水平之间的关联，我们使用了以美洲原住民遗传背景百分比为主要预测因素的四分位逻辑回归模型。
平均 HDL 水平为 38.9mg/dL，有 62%的受试者 HDL 水平低于 40mg/dL。参与者平均有 53.6%的美洲原住民遗传背景、39%的欧洲遗传背景和 7.3%的非洲遗传背景。与第一四分位组相比，第四四分位组的个体具有低 HDL-胆固醇的几率高 35%（比值比，1.35；95%置信区间，0.99-1.81），调整社会经济水平和其他协变量后，尽管这种关联呈非线性。
美洲原住民遗传背景似乎在低 HDL 胆固醇水平的发展中起着微小但明显的作用。
