哮喘中的IgG亚类缺陷
IgG subclass deficiency in asthma.
作者信息
Loftus B G, Price J F, Lobo-Yeo A, Vergani D
机构信息
Department of Child Health, King's College School of Medicine and Dentistry, London.
出版信息
Arch Dis Child. 1988 Dec;63(12):1434-7. doi: 10.1136/adc.63.12.1434.
Abstract
Total immunoglobulin G (IgG) and subclasses were measured in serum samples from 82 children with chronic asthma, aged 1.5 to 6.3 years, and 76 controls. Concentrations of IgG1, IgG2, IgG3, and total IgG were significantly lower in asthmatic children aged 1 to 5, and IgG2 concentrations were also significantly lower in asthmatic children over 5 years of age. Twenty eight asthmatic children had at least one value in the deficient range, and 26 had IgG2 deficiency alone or in combination. Five children had IgG2 and IgA deficiency. These 28 children were significantly younger and fewer had raised IgE concentrations than the remainder. IgG subclass deficiency, which may reflect delayed maturation of the immune system, is common in young asthmatic children, and may have a role in the pathogenesis of the disease.
摘要
对82名年龄在1.5至6.3岁的慢性哮喘儿童和76名对照儿童的血清样本进行了总免疫球蛋白G（IgG）及其亚类检测。1至5岁哮喘儿童的IgG1、IgG2、IgG3和总IgG浓度显著降低，5岁以上哮喘儿童的IgG2浓度也显著降低。28名哮喘儿童至少有一项指标处于缺乏范围，26名儿童单独或合并存在IgG2缺乏。5名儿童存在IgG2和IgA缺乏。这28名儿童比其余儿童明显更年幼，且IgE浓度升高的儿童更少。IgG亚类缺乏可能反映免疫系统成熟延迟，在年幼哮喘儿童中很常见，可能在疾病发病机制中起作用。
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