Distefano Giulio, Fanzone Luigi, Palermo Monica, Tiralongo Francesco, Cosentino Salvatore, Inì Corrado, Galioto Federica, Vancheri Ada, Torrisi Sebastiano E, Mauro Letizia A, Foti Pietro V, Vancheri Carlo, Palmucci Stefano, Basile Antonio
Radiology Unit 1, Department of Medical Surgical Sciences and Advanced Technologies "GF Ingrassia"-University Hospital "Policlinico-Vittorio Emanuele", University of Catania, 95123 Catania, Italy.
Department of Clinical and Experimental Medicine, University of Catania, Regional Referral Centre for Rare Lung Disease, 95123 Catania, Italy.
Diagnostics (Basel). 2020 Apr 22;10(4):244. doi: 10.3390/diagnostics10040244.
Interstitial Lung Diseases (ILDs) represent a heterogeneous group of pathologies, which may be related to different causes. A low percentage of these lung diseases may be secondary to the administration of drugs or substances. Through the PubMed database, an extensive search was performed in the fields of drug toxicity and interstitial lung disease. We have evaluated the different classes of drugs associated with pulmonary toxicity. Several different high resolution computed tomography (HRCT) patterns related to pulmonary drug toxicity have been reported in literature, and the most frequent ILDs patterns reported include Nonspecific Interstitial Pneumonia (NSIP), Usual Interstitial Pneumonia (UIP), Hypersensitivity Pneumonitis (HP), Organizing Pneumonia (OP), Acute Respiratory Distress Syndrome (ARDS), and Diffuse Alveolar Damage (DAD). Finally, from the electronic database of our Institute we have selected and commented on some cases of drug-induced lung diseases related to the administration of common drugs. As the imaging patterns are rarely specific, an accurate evaluation of the clinical history is required and a multidisciplinary approach-involving pneumologists, cardiologists, radiologists, pathologists, and rheumatologists-is recommended.
间质性肺疾病（ILDs）是一组异质性疾病，可能与多种不同病因相关。这些肺部疾病中，有一小部分可能继发于药物或物质的使用。通过PubMed数据库，我们在药物毒性和间质性肺疾病领域进行了广泛的检索。我们评估了与肺部毒性相关的不同类别药物。文献中报道了几种与肺部药物毒性相关的不同高分辨率计算机断层扫描（HRCT）模式，最常见的间质性肺疾病模式包括非特异性间质性肺炎（NSIP）、寻常型间质性肺炎（UIP）、过敏性肺炎（HP）、机化性肺炎（OP）、急性呼吸窘迫综合征（ARDS）和弥漫性肺泡损伤（DAD）。最后，我们从本研究所的电子数据库中挑选并评论了一些与常用药物使用相关的药物性肺病病例。由于影像学表现很少具有特异性，因此需要准确评估临床病史，建议采用多学科方法，包括肺科医生、心脏病专家、放射科医生、病理科医生和风湿病专家。
