Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
Nutrients. 2020 Apr 22;12(4):1177. doi: 10.3390/nu12041177.
Combining resistance exercise (RE) with nutrient intake stimulates muscle protein net balance. However, it is still unclear whether the optimal timing of nutrient intake is before or after RE, especially on muscle protein breakdown (MPB) for an augmented muscle anabolic response. The aim of this study was to investigate the effect of a substantial mixed meal (i.e., nutrient- and protein-dense whole foods) before or after RE, compared with RE without a meal on the acute response of MPB in a crossover-design study.
Eight healthy young men performed three trials: (1) meal intake before RE (Pre), (2) meal intake after RE (Post), and (3) RE without meal intake (No). Plasma insulin and 3-methylhistidine (3-MH), an MPB marker, were measured.
Time course change in plasma insulin level after RE was significantly higher in the Post condition than in the Pre and No conditions. The area under the curve of 3-MH concentration was significantly lower in the Post condition than in the Pre and No conditions.
These results suggest that a substantial mixed meal immediately after RE may effectively suppress MPB in the morning.
抗阻运动（RE）与营养摄入相结合可刺激肌肉蛋白质净平衡。然而，目前尚不清楚营养摄入的最佳时机是在 RE 之前还是之后，特别是对于增强肌肉合成代谢反应的肌肉蛋白分解（MPB）。本研究旨在以交叉设计研究的方式，探讨与 RE 后或 RE 后相比，RE 前摄入大量混合膳食（即营养和蛋白质丰富的全食物）对 MPB 的急性反应的影响。
8 名健康年轻男性进行了 3 次试验：（1）RE 前摄入膳食（Pre），（2）RE 后摄入膳食（Post），和（3）RE 无膳食摄入（No）。测量血浆胰岛素和 3-甲基组氨酸（3-MH），一种 MPB 标志物。
RE 后血浆胰岛素水平的时间过程变化在 Post 条件下明显高于 Pre 和 No 条件。3-MH 浓度曲线下面积在 Post 条件下明显低于 Pre 和 No 条件。
这些结果表明，RE 后立即摄入大量混合膳食可能会有效地抑制早晨的 MPB。
