Baylor College of Medicine, Neuroradiology Research Group, Edward B. Singleton Department of Radiology, Texas Children's Hospital, Houston, TX; Edward B. Singleton Department of Radiology, Texas Children's Hospital Houston, TX.
Edward B. Singleton Department of Radiology, Texas Children's Hospital Houston, TX.
Semin Pediatr Neurol. 2020 Apr;33:100797. doi: 10.1016/j.spen.2020.100797. Epub 2020 Jan 22.
Diffusion weighted MRI (DWI) including diffusion tensor imaging (DTI) are unique imaging techniques that render qualitative and quantitative information of the central nervous system white matter (WM) ultrastructure. It uses the Brownian movement of water molecules to probe tissue microstructure. It is a noninvasive method, with superb sensitivity to the differential mobility of water molecules within various components of the brain without the necessity to inject contrast agents. By sampling the 3 dimensional shape, direction and magnitude of the water diffusion, DWI/DTI generates unique tissue contrasts that can be used to study the axonal WM organization of the central nervous system. Its application allows to study the normal and anomalous brain development including connectivity, as well as a multitude of WM diseases. This article discusses/summarizes the principles of DWI/DTI and its applications in pediatric neuroscience research.
扩散加权磁共振成像（DWI）包括扩散张量成像（DTI），是一种独特的成像技术，可提供中枢神经系统白质（WM）超微结构的定性和定量信息。它利用水分子的布朗运动来探测组织的微观结构。这是一种非侵入性的方法，对大脑不同成分内水分子的差异迁移率具有极高的敏感性，而无需注射造影剂。通过对水分子扩散的三维形状、方向和幅度进行采样，DWI/DTI 可产生独特的组织对比，用于研究中枢神经系统的轴突 WM 组织。其应用可用于研究正常和异常的脑发育，包括连接性，以及多种 WM 疾病。本文讨论/总结了 DWI/DTI 的原理及其在儿科神经科学研究中的应用。
