关于带电侧链与α-螺旋主链的相互作用。
On the interactions of charged side chains with the alpha-helix backbone.
作者信息
Godzik A, Wesolowski T
机构信息
Department of Biophysics, Institute, University of Warsaw, Poland.
出版信息
Biophys Chem. 1988 Aug;31(1-2):29-34. doi: 10.1016/0301-4622(88)80005-x.
PMID:3233289
Abstract
The effects of the position of charged amino acid side chains on the stability of the alpha-helix are investigated. Calculations for the model polyAla 13 residue alpha-helix, with modifications based on experimental work, are performed at three levels of approximation. The observed stabilization of the alpha-helix could be explained by interactions between its macrodipole and charged amino acid side chains. Limitations of the model are discussed.
摘要
研究了带电荷氨基酸侧链位置对α-螺旋稳定性的影响。基于实验工作进行了修改，对模型聚丙氨酸13残基α-螺旋在三种近似水平上进行了计算。观察到的α-螺旋稳定性可以通过其大偶极与带电荷氨基酸侧链之间的相互作用来解释。讨论了该模型的局限性。
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