Wanitphakdeedecha Rungsima, Ng Janice Natasha C, Junsuwan Natchaya, Phaitoonwattanakij Sutasinee, Phothong Weeranut, Eimpunth Sasima, Manuskiatti Woraphong
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Cosmet Dermatol. 2020 Jul;19(7):1662-1666. doi: 10.1111/jocd.13457. Epub 2020 May 13.
Olive leaf extract (OLE), a naturally extracted product from olive leaves, contains oleuropein and other bioactive phenolic compounds. Oleuropein was identified to have various medical properties. It was also found to inhibit the effects of both acute and chronic UVB-induced skin damage as well as accelerate wound healing activity.
To evaluate the efficacy of olive leaf extract-containing cream on facial rejuvenation.
This is a prospective pilot study with a total of 36 participants, who presented with photoaging skin. All participants applied the olive leaf extract-containing cream (SUPERHEAL™ O-Live Cream, PhytoCeuticals, Inc, USA) to their whole face twice daily for 2 months. Primary outcomes measured in the study were the changes in the biophysical properties of the skin assessed with the following parameters: melanin and erythema index, transepidermal water loss (TEWL), skin hydration, skin pH, sebum level, texture, and wrinkles.
After 2 months, TEWL decreased significantly (P = .007) and maintained the results 1 month after discontinuation of the treatment (P = .007). Skin hydration also increased significantly after 2 months (P = .004). Wrinkles improved significantly on all follow-ups (P < .001, P = .001, P = .001, respectively). An image of the skin captured using Visioscan® showed improvement of the skin texture 2 months after treatment. Majority of the participants (64%) noted improvement in their skin texture.
Olive leaf extract-containing cream provided benefits on skin rejuvenation in human skin.
橄榄叶提取物（OLE）是从橄榄叶中天然提取的产品，含有橄榄苦苷和其他生物活性酚类化合物。已证实橄榄苦苷具有多种医学特性。还发现它能抑制急性和慢性紫外线诱导的皮肤损伤的影响，并加速伤口愈合。
评估含橄榄叶提取物的面霜对面部年轻化的疗效。
这是一项前瞻性试点研究，共有36名有光老化皮肤的参与者。所有参与者每天两次将含橄榄叶提取物的面霜（SUPERHEAL™ O-Live面霜，美国植物制药公司）涂抹于全脸，持续2个月。该研究中测量的主要结果是通过以下参数评估的皮肤生物物理特性的变化：黑色素和红斑指数、经表皮水分流失（TEWL）、皮肤水合作用、皮肤pH值、皮脂水平、质地和皱纹。
2个月后，TEWL显著降低（P = 0.007），并在停止治疗1个月后保持该结果（P = 0.007）。2个月后皮肤水合作用也显著增加（P = 0.004）。在所有随访中皱纹均有显著改善（分别为P < 0.001、P = 0.001、P = 0.001）。使用Visioscan®拍摄的皮肤图像显示治疗2个月后皮肤质地有所改善。大多数参与者（64%）表示皮肤质地有所改善。
含橄榄叶提取物的面霜对人类皮肤的年轻化有益。
