IRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Via Palermo, C. da Casazza, 98124, Messina, Italy.
J Headache Pain. 2020 Apr 25;21(1):39. doi: 10.1186/s10194-020-01109-2.
Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.
We analyzed brain morphologic images of migraine patients, 14 with aura (MwA) [the mean (SD) age was 42.36 (2.95) years (range, 37-47)] and 14 without aura (MwoA) [the mean (SD) age was 43.5 (3.25) years (range, 39-50)] during episodic attack compared with health subjects balanced (HS) [the mean (SD) age was 42.5 (5.17) years (range, 34-51)]. All subjects underwent a Magnetic Resonance Imaging (MRI) examination with a scanner operating at 3.0 T and voxel based morphometry (VBM) approach was used to examine the gray matter volume (GMV). The statistical analysis to compare clinicl characteristics was performed using unpaired t-test an one-way Anova.
Total cerebral GMV showed a significant difference between MwA and HS (p = 0.02), and between MwoA and HS (p = 0.003). In addition, not significative differences were found between MwA and MwoA groups (p = 0.17). We found three clusters of regions which showed significant GMV reduction in MwA compared with MwoA. MwA subjects showed a less of GMV in 4 clusters if compared with HS, and MwoA subjects showed a less of GMV in 3 clusters if compared with HS. We observed that MwA and MwoA patients had a significant reduction of GMV in the frontal and temporal lobe and the cerebellum, if compared to HS. The bilateral fusiform gyrus and the cingulate gyrus were increase in MwoA patients compared with HS.
Our findings could provide a approach to understand possible differences in the pathogenesis of two type of migraine.
偏头痛是一种常见的神经系统疾病，其特征为复杂的病理生理学。我们评估了偏头痛患者的脑形态差异，以及该疾病潜在的发病机制。
我们分析了 14 例有先兆偏头痛（MwA）患者（平均年龄为 42.36±2.95 岁，范围为 37-47 岁）和 14 例无先兆偏头痛（MwoA）患者（平均年龄为 43.5±3.25 岁，范围为 39-50 岁）在发作期的脑形态图像，与健康对照者（HS）进行比较（平均年龄为 42.5±5.17 岁，范围为 34-51 岁）。所有受试者均进行了 3.0T 磁共振成像（MRI）检查，采用基于体素的形态计量学（VBM）方法检查灰质体积（GMV）。使用独立样本 t 检验和单因素方差分析比较临床特征的统计分析。
MwA 与 HS 之间（p=0.02）以及 MwoA 与 HS 之间（p=0.003）总脑 GMV 存在显著差异。此外，MwA 与 MwoA 组之间未发现显著差异（p=0.17）。我们发现 MwA 与 MwoA 相比，有三个区域的 GMV 显著减少。与 HS 相比，MwA 组有 4 个 GMV 减少的脑区，MwoA 组有 3 个 GMV 减少的脑区。我们观察到，与 HS 相比，MwA 和 MwoA 患者的额叶、颞叶和小脑 GMV 明显减少。与 HS 相比，MwoA 患者的双侧梭状回和扣带回 GMV 增加。
我们的发现可能为理解两种偏头痛发病机制的可能差异提供一种方法。
