Foti Maria, Lo Buono Viviana, Corallo Francesco, Palmeri Rosanna, Bramanti Placido, Marino Silvia
IRCCS Centro Neurolesi "Bonino-Pulejo", Clinical Neuroscience and Neurobioimaging, S.S. 113 Via Palermo, C.da Casazza, 98124, Messina, Italy.
Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.
Neurol Sci. 2017 Apr;38(4):553-562. doi: 10.1007/s10072-017-2814-z. Epub 2017 Jan 18.
Migraine is considered a disabling disorder with highly prevalence in population. Recent studies report that migraine patients have a cognitive decline associated to structural brain alterations. We search on PubMed and Web of Science databases and screening references of included studies and review articles for additional citations. From 519 studies identified, only 16 met the inclusion criteria. All studies were conducted on 1479 migraineurs (190 non-migraine headache and 11,978 controls subject) and examined the association between migraine and cognitive impairment. The results are discordant. Indeed, while cognitive deficits during the attack of migraine are now recognized, only few studies confirmed the presence of cognitive impairment in migraine patients. Given the prevalence of migraine in the population (especially among women), and the early age of the population, an association between migraine and cognitive impairment could have substantial public health implications. Future studies should determine if specific migraine characteristics, for example, attack frequency, may impact the association between migraine and cognitive decline.
偏头痛被认为是一种致残性疾病，在人群中具有很高的患病率。最近的研究报告称，偏头痛患者存在与大脑结构改变相关的认知衰退。我们在PubMed和科学网数据库中进行检索，并筛选纳入研究和综述文章的参考文献以获取更多引用。从519项已识别的研究中，只有16项符合纳入标准。所有研究均针对1479名偏头痛患者（190名非偏头痛性头痛患者和11978名对照受试者）进行，并研究了偏头痛与认知障碍之间的关联。结果不一致。事实上，虽然现在已经认识到偏头痛发作期间存在认知缺陷，但只有少数研究证实偏头痛患者存在认知障碍。鉴于偏头痛在人群中的患病率（尤其是在女性中）以及发病年龄较早，偏头痛与认知障碍之间的关联可能对公共卫生具有重大影响。未来的研究应确定特定的偏头痛特征，例如发作频率，是否会影响偏头痛与认知衰退之间 的关联。
