J Pediatr Health Care. 2020 May-Jun;34(3):291-300. doi: 10.1016/j.pedhc.2019.11.001.
Acute otitis media, acute bacterial rhinosinusitis, and community-acquired pneumonia are major drivers of pediatric antibiotic consumption. With many available options and the added challenges of navigating antibiotic allergies and de-escalating from intravenous treatment for children requiring hospitalization, prescribing for these relatively simple infections can be a source of confusion and error. The purpose of this article is to evaluate the pharmacokinetic and pharmacodynamic properties of antibiotics commonly prescribed for these disease states, and to specifically compare antipneumococcal activity between oral beta-lactams.
急性中耳炎、急性细菌性鼻-鼻窦炎和社区获得性肺炎是导致儿科抗生素使用的主要因素。由于有许多可用的选择，以及在治疗需要住院的儿童时要应对抗生素过敏和从静脉治疗降级的额外挑战，为这些相对简单的感染开具处方可能会导致混淆和错误。本文的目的是评估常用于治疗这些疾病的抗生素的药代动力学和药效学特性，并特别比较口服β-内酰胺类药物的抗肺炎球菌活性。
