Langerholc Tomaz, Maragkoudakis Petros A, Wollgast Jan, Gradisnik Lidija, Cencic Avrelija
Dep. of Microbiology, Biochemistry, Molecular Biology and Biotechnology, Faculty of Agriculture and Life Science, University of Maribor, Pivola 10, 2311 Hoce, Slovenia.
European Commission - Joint Research Centre - Institute for Health and Consumer Protection, Via Enrico Fermi 2749, 21027 Ispra (VA), Italy.
Trends Food Sci Technol. 2011 Nov;22:S11-S20. doi: 10.1016/j.tifs.2011.03.010. Epub 2011 Apr 9.
This review presents the applications of intestinal cell models of human and pig origin in food and nutritional sciences and highlights their potential as platforms for preclinical research. Intestinal cell models are used in studies of bioavailability, adsorption and transport in nutritional or toxicological settings, allergic effects of food components, as well as probiotics and/or host-pathogen gut interactions. In addition, this review discusses the advantages of using specialized and functional cell models over generic cancer-derived cell lines.
本综述介绍了人和猪源肠道细胞模型在食品和营养科学中的应用，并强调了它们作为临床前研究平台的潜力。肠道细胞模型用于营养或毒理学环境中的生物利用度、吸附和转运研究、食品成分的过敏效应以及益生菌和/或宿主-病原体肠道相互作用的研究。此外，本综述还讨论了使用专门的功能性细胞模型相对于普通癌症衍生细胞系的优势。
