非编码 RNA 作为急性冠状动脉综合征的生物标志物。
Noncoding RNAs as Biomarkers for Acute Coronary Syndrome.
机构信息
Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, China.
出版信息
Biomed Res Int. 2020 Apr 1;2020:3298696. doi: 10.1155/2020/3298696. eCollection 2020.
Abstract
Acute coronary syndrome (ACS), consisting of acute myocardial infarction and unstable angina, is the most dangerous and fatal form of coronary heart disease. Acute coronary syndrome has sudden onset and rapid development, which may lead to malignant life-threatening conditions at any time. Therefore, early detection and diagnosis are critical for patients with ACS. Recent studies have found that noncoding RNA is of great significance in the diagnosis and treatment of cardiovascular diseases. In this review, we summarized recent data on circulating noncoding RNAs (including microRNA, long noncoding RNA, and circular RNA) as diagnostic and prognostic markers in ACS including acute myocardial infarction and unstable angina. Specifically, microRNAs (miRNAs) as diagnostic markers are divided into three types: miRNAs of increased expression in ACS, miRNAs of decreased expression in ACS, and miRNAs of contradictory expression in ACS. Moreover, we described these miRNAs of increased expression in ACS based on miRNAs family. This review may result in a great guidance of noncoding RNAs as biomarkers for ACS in clinical practice.
摘要
急性冠状动脉综合征（ACS）包括急性心肌梗死和不稳定型心绞痛，是冠心病中最危险和最致命的形式。急性冠状动脉综合征发病突然，发展迅速，随时可能导致危及生命的恶性情况。因此，ACS 患者的早期检测和诊断至关重要。最近的研究发现，非编码 RNA 在心血管疾病的诊断和治疗中具有重要意义。在这篇综述中，我们总结了最近关于循环非编码 RNA（包括 microRNA、长非编码 RNA 和环状 RNA）作为急性心肌梗死和不稳定型心绞痛等 ACS 诊断和预后标志物的研究数据。具体来说，作为诊断标志物的 microRNAs（miRNAs）分为三类：ACS 中表达增加的 miRNAs、ACS 中表达减少的 miRNAs 和 ACS 中表达矛盾的 miRNAs。此外，我们根据 miRNAs 家族描述了 ACS 中表达增加的这些 miRNAs。这篇综述可能会对非编码 RNA 作为 ACS 临床实践中的生物标志物产生重要的指导作用。
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