Stote Kim S, Wilson Margaret M, Hallenbeck Deborah, Thomas Krista, Rourke Joanne M, Sweeney Marva I, Gottschall-Pass Katherine T, Gosmanov Aidar R
Department of Research, Stratton VA Medical Center, Albany, NY, USA.
Department of Endocrinology, Stratton VA Medical Center, Albany, USA.
Curr Dev Nutr. 2020 Mar 9;4(4):nzaa030. doi: 10.1093/cdn/nzaa030. eCollection 2020 Apr.
Blueberries are dietary sources of polyphenols, specifically anthocyanins. Anthocyanins have been identified as having a strong association with type 2 diabetes risk reduction; however, to date few human clinical trials have evaluated the potential beneficial health effects of blueberries in populations with type 2 diabetes.
We investigated the effects of blueberry consumption for 8 wk on cardiometabolic parameters in men with type 2 diabetes.
In a double-blind, parallel-arm, randomized controlled trial, 52 men who are US veterans [mean baseline characteristics: age, 67 y (range: 51-75 y); weight, 102 kg (range: 80-130 kg); BMI (in kg/m), 34 (range: 26-45)] were randomly assigned to 1 of 2 intervention groups. The interventions were either 22 g freeze-dried blueberries or 22 g placebo. The study participants were asked to consume 11 g freeze-dried blueberries or placebo with each of their morning and evening meals along with their typical diet.
Mean ± SE hemoglobin A1c (7.1% ± 0.1% compared with 7.5% ± 0.2%; = 0.03), fructosamine (275.5 ± 4.1 compared with 292.4 ± 7.9 µmol/L; = 0.04), triglycerides (179.6 ± 10.1 compared with 199.6 ± 19.9 mg/dL; = 0.03), aspartate transaminase (23.2 ± 1.4 compared with 30.5 ± 2.7 units/L; = 0.02), and alanine transaminase (35.6 ± 1.5 compared with 48.3 ± 2.9 units/L; = 0.0003) were significantly lower for those consuming blueberries for 8 wk than for those consuming the placebo. Fasting plasma glucose concentrations; serum insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, and C-reactive protein concentrations; blood pressure; and body weight were not significantly different after 8 wk consumption of blueberries compared with the placebo.
Consumption of 22 g freeze-dried blueberries for 8 wk may beneficially affect cardiometabolic health parameters in men with type 2 diabetes.This trial was registered at clinicaltrials.gov as NCT02972996.
蓝莓是多酚类物质，特别是花青素的膳食来源。花青素已被确定与降低2型糖尿病风险密切相关；然而，迄今为止，很少有人类临床试验评估蓝莓对2型糖尿病患者潜在的有益健康影响。
我们研究了2型糖尿病男性食用蓝莓8周对心脏代谢参数的影响。
在一项双盲、平行组、随机对照试验中，52名美国退伍军人男性（平均基线特征：年龄67岁，范围51 - 75岁；体重102千克，范围80 - 130千克；体重指数，34，范围26 - 45）被随机分配到2个干预组中的1组。干预措施为22克冻干蓝莓或22克安慰剂。研究参与者被要求在早晚餐时与他们的常规饮食一起食用11克冻干蓝莓或安慰剂。
食用蓝莓8周的参与者的平均±标准误糖化血红蛋白（7.1% ± 0.1%，相比之下安慰剂组为7.5% ± 0.2%；P = 0.03）、果糖胺（275.5 ± 4.1，相比之下安慰剂组为292.4 ± 7.9微摩尔/升；P = 0.04）、甘油三酯（179.6 ± 10.1，相比之下安慰剂组为199.6 ± 19.9毫克/分升；P = 0.03）、天冬氨酸转氨酶（23.2 ± 1.4，相比之下安慰剂组为30.5 ± 2.7单位/升；P = 0.02）和丙氨酸转氨酶（35.6 ± 1.5，相比之下安慰剂组为48.3 ± 2.9单位/升；P = 0.0003）显著低于食用安慰剂的参与者。与安慰剂相比，食用蓝莓8周后空腹血糖浓度、血清胰岛素、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和C反应蛋白浓度、血压及体重无显著差异。
2型糖尿病男性食用22克冻干蓝莓8周可能对心脏代谢健康参数产生有益影响。本试验在clinicaltrials.gov上注册为NCT02972996。
