Zhang Nan, Liu Di, Wei Shuxiang, Cao Shijie, Feng Xinchi, Wang Kai, Ding Liqin, Qiu Feng
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai Dist, Tianjin, 301617 People's Republic of China.
2Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
BMC Chem. 2020 Apr 22;14(1):31. doi: 10.1186/s13065-020-00685-3. eCollection 2020 Dec.
Three new phenylethanol glycosides (-) and one known analogue () were isolated from the seeds of Bge. var. . To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of , which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl-induced cytotoxicity in PC12 cells and compound exhibited moderate activity.
从宁夏枸杞变种的种子中分离出三种新的苯乙醇苷(-)和一种已知类似物()。据我们所知,这是首次从枸杞属植物中分离出苯乙醇苷,丰富了其化学成分。通过广泛的核磁共振(NMR)和高分辨电喷雾电离质谱(HRESIMS)数据以及与文献数据比较进行结构解析。此后,对分离出的化合物进行了针对氯化钴诱导的PC12细胞细胞毒性的神经保护活性测定,化合物表现出中等活性。