七叶树种子中的抗病毒黄酮类化合物。

Antiviral flavonoids from the seeds of Aesculus chinensis.

作者信息

Wei Feng, Ma Shuang-Cheng, Ma Lin-Yun, But Paul Pui-Hay, Lin Rui-Chao, Khan Ikhlas A

机构信息

National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, Beijing 100050, People's Republic of China.

出版信息

J Nat Prod. 2004 Apr;67(4):650-3. doi: 10.1021/np030470h.

DOI:10.1021/np030470h

PMID:15104496

Abstract

A bioassay-guided fractionation of an ethanol extract of the seeds of Aesculus chinensis led to the isolation of two new flavanoids (1 and 2), along with eight known ones (3-10). The structures of the new compounds were elucidated by spectroscopic methods including 2D NMR. All compounds were tested for antiviral activity against respiratory syncytial virus (RSV), parainfluenza virus type 3 (PIV 3), and influenza virus type A (Flu A). Compounds 1, 2, and 6 showed significant antiviral activities against RSV with IC(50) values of 4.5, 6.7, and 4.1 microg/mL and selective index (SI) values of 15.8, 32, and 63.8, respectively. Compound 8 demonstrated significant antiviral activity against Flu A with an IC(50) of 24.5 microg/mL and a SI of 16.0, respectively.

摘要

对七叶树种子乙醇提取物进行生物活性导向的分离，得到了两种新的黄酮类化合物（1和2）以及八种已知化合物（3 - 10）。通过包括二维核磁共振在内的光谱方法阐明了新化合物的结构。对所有化合物进行了抗呼吸道合胞病毒（RSV）、3型副流感病毒（PIV 3）和甲型流感病毒（Flu A）的抗病毒活性测试。化合物1、2和6对RSV显示出显著的抗病毒活性，IC(50)值分别为4.5、6.7和4.1微克/毫升，选择性指数（SI）值分别为15.8、32和63.8。化合物8对Flu A显示出显著的抗病毒活性，IC(50)为24.5微克/毫升，SI为16.0。