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七叶树种子中的三萜皂苷及其细胞毒性

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities.

作者信息

Cheng Jin-Tang, Chen Shi-Tao, Guo Cong, Jiao Meng-Jiao, Cui Wen-Jin, Wang Shu-Hui, Deng Zhe, Chen Chang, Chen Sha, Zhang Jun, Liu An

机构信息

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

出版信息

Nat Prod Bioprospect. 2018 Feb;8(1):47-56. doi: 10.1007/s13659-017-0148-4. Epub 2017 Dec 29.

DOI:10.1007/s13659-017-0148-4
PMID:29285602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5803144/
Abstract

Six new triterpenoid saponins, aesculusosides A-F (1-6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23-25 exhibited inhibitory activities against MCF-7 with IC values ranging from 7.1 to 31.3 μM.

摘要

从七叶树种子中分离出6个新的三萜皂苷，七叶皂苷A-F（1-6），以及19个已知的三萜皂苷。通过广泛的光谱分析并与先前报道的数据进行比较，阐明了新结构。通过MTT法对部分分离物进行了抗MCF-7细胞系的细胞毒活性评价，化合物15、16、19和23-25对MCF-7表现出抑制活性，IC值范围为7.1至31.3 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b869/5803144/8d8229016f6b/13659_2017_148_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b869/5803144/6361ee25403c/13659_2017_148_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b869/5803144/8d8229016f6b/13659_2017_148_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b869/5803144/6361ee25403c/13659_2017_148_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b869/5803144/8d8229016f6b/13659_2017_148_Fig2_HTML.jpg

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本文引用的文献

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Beneficial effects of Aesculus hippocastanum L. seed extract on the body's own antioxidant defense system on subacute administration.七叶树种子提取物对亚急性给药时机体自身抗氧化防御系统的有益作用。
J Ethnopharmacol. 2010 May 4;129(1):18-22. doi: 10.1016/j.jep.2010.02.017. Epub 2010 Feb 26.
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Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma.七叶皂苷是一种天然的三萜皂苷混合物，具有抗肝癌活性。
Planta Med. 2009 Dec;75(15):1580-5. doi: 10.1055/s-0029-1185838.
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Beta-escin, a natural triterpenoid saponin from Chinese horse chestnut seeds, depresses HL-60 human leukaemia cell proliferation and induces apoptosis.
非洲富含肥皂草皂苷植物清单，可用于社区应对全球大流行。
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Phenylethanol glycosides from the seeds of var. .来自变种种子的苯乙醇苷类化合物 。 （原文似乎不完整，信息不太明确，仅根据现有内容直接翻译）
BMC Chem. 2020 Apr 22;14(1):31. doi: 10.1186/s13065-020-00685-3. eCollection 2020 Dec.
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J Pharm Pharmacol. 2008 Sep;60(9):1213-20. doi: 10.1211/jpp.60.9.0014.
4
Beta-aescin: a potent natural inhibitor of proliferation and inducer of apoptosis in human chronic myeloid leukemia K562 cells in vitro.β-七叶皂苷：一种在体外对人慢性髓性白血病K562细胞具有强大增殖抑制和凋亡诱导作用的天然抑制剂。
Leuk Lymphoma. 2008 Jul;49(7):1384-91. doi: 10.1080/10428190802090151.
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Mol Cancer Ther. 2006 Jun;5(6):1459-66. doi: 10.1158/1535-7163.MCT-05-0495.
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Antioxidative and antigenotoxic effects of Japanese horse chestnut (Aesculus turbinata) seeds.日本七叶树（Aesculus turbinata）种子的抗氧化和抗遗传毒性作用。
J Vet Med Sci. 2005 Jul;67(7):731-4. doi: 10.1292/jvms.67.731.
7
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8
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