七叶树种子中的三萜皂苷及其细胞毒性
Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities.
作者信息
Cheng Jin-Tang, Chen Shi-Tao, Guo Cong, Jiao Meng-Jiao, Cui Wen-Jin, Wang Shu-Hui, Deng Zhe, Chen Chang, Chen Sha, Zhang Jun, Liu An
机构信息
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
出版信息
Nat Prod Bioprospect. 2018 Feb;8(1):47-56. doi: 10.1007/s13659-017-0148-4. Epub 2017 Dec 29.
Six new triterpenoid saponins, aesculusosides A-F (1-6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23-25 exhibited inhibitory activities against MCF-7 with IC values ranging from 7.1 to 31.3 μM.
从七叶树种子中分离出6个新的三萜皂苷，七叶皂苷A-F（1-6），以及19个已知的三萜皂苷。通过广泛的光谱分析并与先前报道的数据进行比较，阐明了新结构。通过MTT法对部分分离物进行了抗MCF-7细胞系的细胞毒活性评价，化合物15、16、19和23-25对MCF-7表现出抑制活性，IC值范围为7.1至31.3 μM。
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