Prior C, Frank A, Fuchs D, Hausen A, Judmaier G, Reibnegger G, Werner E R, Wachter H
Department of Medicine, University Hospital, Innsbruck, Austria.
Clin Chim Acta. 1988 Oct 31;177(3):211-20. doi: 10.1016/0009-8981(88)90065-4.
Urinary neopterin levels were determined by high pressure liquid chromatography in 36 patients with pulmonary sarcoidosis. Values were above normal range in 69.4% of all patients. Neopterin excretion was significantly higher in radiologic types II/III than in type I disease (p = 0.0265, Mann-Whitney U-test). Urinary neopterin showed a weak, but significant inverse correlation to disease duration (r = -0.36; p = 0.034, Spearman's rank correlation). No significant correlation could be found between neopterin and the presence of pulmonary or extrapulmonary symptoms, vital capacity, forced expiratory volume in the first second, steroid treatment, and serum angiotensin converting enzyme. Follow-up studies revealed that worsening or improvement of chest X-ray findings was invariably accompanied by rising or decreasing neopterin excretion, respectively. Patients with normal neopterin at initial evaluation had a higher tendency towards spontaneous healing, and none of them deteriorated during the follow-up period. We conclude that urinary neopterin excretion reflects one aspect of alveolitic "activity" in pulmonary sarcoidosis and that normal values probably indicate a favorable prognosis.
采用高压液相色谱法测定了36例肺结节病患者的尿新蝶呤水平。所有患者中69.4%的值高于正常范围。放射学类型为II/III型的患者新蝶呤排泄显著高于I型疾病患者（p = 0.0265，曼-惠特尼U检验）。尿新蝶呤与病程呈弱但显著的负相关（r = -0.36；p = 0.034，斯皮尔曼等级相关）。新蝶呤与肺部或肺外症状的存在、肺活量、第一秒用力呼气量、类固醇治疗及血清血管紧张素转换酶之间未发现显著相关性。随访研究显示，胸部X线表现的恶化或改善分别总是伴随着新蝶呤排泄的增加或减少。初始评估时新蝶呤正常的患者自发愈合倾向较高，且在随访期间均未恶化。我们得出结论，尿新蝶呤排泄反映了肺结节病中肺泡炎“活动”的一个方面，正常数值可能预示着良好的预后。
