在小鼠中，重复间歇性给予（S）-氯胺酮而非（R）-氯胺酮后出现精神病的风险。 - Suppr

Risk of psychosis after repeated intermittent administration of (S)-ketamine, but not (R)-ketamine, in mice.

作者信息

Tan Yunfei, Hashimoto Kenji

机构信息

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan.

出版信息

J Affect Disord. 2020 May 15;269:198-200. doi: 10.1016/j.jad.2020.03.040. Epub 2020 Apr 2.

DOI:10.1016/j.jad.2020.03.040

PMID:32339136

Abstract

摘要

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Risk of psychosis after repeated intermittent administration of (S)-ketamine, but not (R)-ketamine, in mice.在小鼠中，重复间歇性给予（S）-氯胺酮而非（R）-氯胺酮后出现精神病的风险。

J Affect Disord. 2020 May 15;269:198-200. doi: 10.1016/j.jad.2020.03.040. Epub 2020 Apr 2.

Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine.比较（R，S）-氯胺酮、（R）-氯胺酮和（S）-氯胺酮经鼻内给药后小鼠的抗抑郁作用和副作用。

Pharmacol Biochem Behav. 2019 Jun;181:53-59. doi: 10.1016/j.pbb.2019.04.008. Epub 2019 Apr 26.

MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling.（R）-氯胺酮经鼻腔给药后可减轻小鼠脑内 MPTP 诱导的多巴胺能神经毒性：TrkB 信号的作用。

Psychopharmacology (Berl). 2020 Jan;237(1):83-92. doi: 10.1007/s00213-019-05346-5. Epub 2019 Aug 15.

Antidepressant Potential of ()-Ketamine in Rodent Models: Comparison with ()-Ketamine.（-）-氯胺酮在啮齿动物模型中的抗抑郁潜力：与（+）-氯胺酮的比较。

J Pharmacol Exp Ther. 2017 Apr;361(1):9-16. doi: 10.1124/jpet.116.239228. Epub 2017 Jan 23.

Is the History Repeated? Can (2,6)-Hydroxynorketamine be Another Antidepressant?历史会重演吗？(2,6)-羟基去甲氯胺酮会成为另一种抗抑郁药吗？

J Exp Neurosci. 2018 Dec 4;12:1179069518815445. doi: 10.1177/1179069518815445. eCollection 2018.

Reinforcing properties of an intermittent, low dose of ketamine in rats: effects of sex and cycle.间歇性低剂量氯胺酮对大鼠的强化特性：性别和周期的影响

Psychopharmacology (Berl). 2017 Feb;234(3):393-401. doi: 10.1007/s00213-016-4470-z. Epub 2016 Nov 11.

The repeated administration of ketamine induces an enhancement of its stimulant action in mice.氯胺酮的重复给药会增强其对小鼠的兴奋作用。

Jpn J Pharmacol. 1993 Feb;61(2):149-51. doi: 10.1254/jjp.61.149.

Intermittent administration of low dose ketamine can shorten the course of electroconvulsive therapy for depression and reduce complications: A randomized controlled trial.间歇给予小剂量氯胺酮可以缩短电抽搐治疗抑郁症的疗程并减少并发症：一项随机对照试验。

Psychiatry Res. 2019 Nov;281:112573. doi: 10.1016/j.psychres.2019.112573. Epub 2019 Sep 23.

Prepulse inhibition of the startle reflex and its attentional modulation in the human S-ketamine and N,N-dimethyltryptamine (DMT) models of psychosis.在人类精神分裂症的S-氯胺酮和N,N-二甲基色胺（DMT）模型中，惊吓反射的前脉冲抑制及其注意力调节。

J Psychopharmacol. 2007 May;21(3):312-20. doi: 10.1177/0269881107077734.

Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET).在健康志愿者中使用正电子发射断层扫描（PET）研究（S）-氯胺酮和（R）-氯胺酮产生的差异心理病理学及脑葡萄糖利用模式。

Eur Neuropsychopharmacol. 1997 Feb;7(1):25-38. doi: 10.1016/s0924-977x(96)00042-9.

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Behavioral sensitization and tolerance induced by repeated treatment with ketamine enantiomers in male Wistar rats.反复使用（±）-氯胺酮对雄性 Wistar 大鼠的行为敏化和耐受诱导作用。

PLoS One. 2024 Mar 1;19(3):e0299379. doi: 10.1371/journal.pone.0299379. eCollection 2024.

Are "mystical experiences" essential for antidepressant actions of ketamine and the classic psychedelics?“神秘体验”对于氯胺酮和经典致幻剂的抗抑郁作用是否至关重要？

Eur Arch Psychiatry Clin Neurosci. 2024 Feb 27. doi: 10.1007/s00406-024-01770-7.

The effect of esketamine combined with propofol-induced general anesthesia on cerebral blood flow velocity: a randomized clinical trial.依托咪酯和氯胺酮复合全身麻醉对脑血流速度的影响：一项随机临床试验。

BMC Anesthesiol. 2024 Feb 20;24(1):66. doi: 10.1186/s12871-024-02446-4.

Safety and Tolerability of the Acute Ketamine Treatment in Treatment-Resistant Depression: Focus on Comorbidities Interplay with Dissociation and Psychomimetic Symptoms.难治性抑郁症急性氯胺酮治疗的安全性和耐受性：关注合并症与解离及拟精神病症状的相互作用。

Pharmaceuticals (Basel). 2023 Jan 24;16(2):173. doi: 10.3390/ph16020173.

Arketamine for cognitive impairment in psychiatric disorders.氯胺酮治疗精神障碍的认知障碍。

Eur Arch Psychiatry Clin Neurosci. 2023 Oct;273(7):1513-1525. doi: 10.1007/s00406-023-01570-5. Epub 2023 Feb 14.

Repeated intermittent administration of (R)-ketamine during juvenile and adolescent stages prevents schizophrenia-relevant phenotypes in adult offspring after maternal immune activation: a role of TrkB signaling.在幼年和青少年阶段反复间歇性给予（R）-氯胺酮可预防母体免疫激活后成年后代的精神分裂症相关表型：TrkB 信号的作用。

Eur Arch Psychiatry Clin Neurosci. 2022 Jun;272(4):693-701. doi: 10.1007/s00406-021-01365-6. Epub 2022 Jan 3.

Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor.亚胺培南抗抑郁作用的分子机制：超越 NMDA 受体。

Mol Psychiatry. 2022 Jan;27(1):559-573. doi: 10.1038/s41380-021-01121-1. Epub 2021 May 7.

Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability.氯胺酮对映异构体的药理学和行为学差异：对滥用倾向的影响。

Mol Psychiatry. 2021 Nov;26(11):6704-6722. doi: 10.1038/s41380-021-01093-2. Epub 2021 Apr 15.

Rapid-acting and long-lasting antidepressant-like action of (R)-ketamine in Nrf2 knock-out mice: a role of TrkB signaling.Nrf2 敲除小鼠中（R）-氯胺酮的快速起效和长效抗抑郁作用：TrkB 信号的作用。

Eur Arch Psychiatry Clin Neurosci. 2021 Apr;271(3):439-446. doi: 10.1007/s00406-020-01208-w. Epub 2020 Nov 12.

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Risk of psychosis after repeated intermittent administration of (S)-ketamine, but not (R)-ketamine, in mice.

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