Inbaraj R M, Haider S
Department of Zoology, Banaras Hindu University, Varanasi, India.
Ecotoxicol Environ Saf. 1988 Oct;16(2):123-8. doi: 10.1016/0147-6513(88)90025-5.
The effect of sublethal concentrations of malathion (organophosphorus insecticide) and endosulfan (organochlorine insecticide) was investigated in Channa punctatus. Brain acetylcholinesterase (AchE) and ovarian delta 5,3 beta-hydroxysteroid dehydrogenase (delta 5,3 beta-HSD) and glucose-6-phosphate dehydrogenase (G-6-PD) activities were studied. Apart from the loss of stage II and III oocytes, the absence of delta 5,3 beta-HSD and G-6-PD activity indicating the inhibition of steroidogenesis was seen in the malathion- and endosulfan-treated fish ovaries. Malathion demonstrated a dose-dependent inhibition of brain AchE activity, whereas endosulfan caused no significant reduction of AchE activity.
研究了马拉硫磷（有机磷杀虫剂）和硫丹（有机氯杀虫剂）亚致死浓度对斑鳢的影响。研究了脑乙酰胆碱酯酶（AchE）、卵巢δ5,3β-羟基类固醇脱氢酶（δ5,3β-HSD）和葡萄糖-6-磷酸脱氢酶（G-6-PD）的活性。除了II期和III期卵母细胞的损失外，在马拉硫磷和硫丹处理的鱼卵巢中还观察到δ5,3β-HSD和G-6-PD活性的缺失，这表明类固醇生成受到抑制。马拉硫磷对脑AchE活性表现出剂量依赖性抑制，而硫丹对AchE活性没有显著降低作用。
