Division of Head and Neck Oncology, Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, James Cancer Center and Solove Research Institute, Columbus, Ohio, USA.
Department of Otolaryngology-Head and Neck Surgery and Department of Genetics, Washington University School of Medicine, Ear, Nose & Throat Center, St. Louis, Missouri, USA.
Head Neck. 2020 Jun;42(6):1218-1226. doi: 10.1002/hed.26217. Epub 2020 Apr 30.
Pulmonary complications and infections frequently affect patients with head and neck squamous cell carcinoma (HNSCC). Common characteristics can predispose these patients to the development of severe respiratory illness, which may be particularly relevant during the 2019 coronavirus disease (COVID-19) pandemic.
A scoping review was performed to assess the impact of pulmonary comorbidities and adverse respiratory outcomes in HNSCC patients.
Advanced age, history of tobacco and alcohol abuse, and cardiopulmonary comorbidities are significant risk factors for the development of adverse respiratory outcomes. Treatment toxicities from radiation or chemoradiation therapy significantly increase these risks.
Respiratory complications are a frequent cause of morbidity and mortality among HNSCC patients, and the COVID-19 pandemic may disproportionately affect this population. Interventions designed to decrease smoking and alcohol use, improve oral hygiene, and aggressively manage medical comorbidities are important to the long-term management and health of these patients.
肺部并发症和感染常影响头颈部鳞状细胞癌（HNSCC）患者。常见特征可能使这些患者易发生严重呼吸道疾病，这在 2019 年冠状病毒病（COVID-19）大流行期间可能尤为相关。
进行了范围综述，以评估肺部合并症和 HNSCC 患者不良呼吸结局的影响。
高龄、吸烟和酗酒史以及心肺合并症是发生不良呼吸结局的重要危险因素。来自放疗或放化疗的治疗毒性显著增加了这些风险。
呼吸并发症是 HNSCC 患者发病率和死亡率的常见原因，COVID-19 大流行可能不成比例地影响这一人群。旨在减少吸烟和饮酒、改善口腔卫生以及积极治疗合并症的干预措施对于这些患者的长期管理和健康非常重要。
