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新冠病毒病对头颈鳞状细胞癌患者有何影响?

What is the impact of COVID-19 on head and neck squamous cell carcinoma patients?

作者信息

Dolan Sean

机构信息

DCT2, Oral and Maxillofacial Surgery, Ninewells Hospital, Dundee, UK.

出版信息

Evid Based Dent. 2020 Jun;21(2):52-53. doi: 10.1038/s41432-020-0091-9.

Abstract

Data sources It is not made clear in this review the different databases selected or how they conducted their search. The studies used are from 1975-2020Study selection The authors have performed a scoping review using 84 studies ranging from 1975-2020. The majority of these are from before the 2019-2020 COVID-19 outbreak period. This is indicative of the lack of evidence on this topic and exemplifies why a scoping review was carried out rather than a systematic review. The studies that were reviewed were predominately cohort and case studies. With regards to previous treatment outcomes, a few systematic reviews were included, but again, the novel nature of this outbreak means that largely, there are only cohort or case studies available for review.Data extraction and synthesis There are ten authors, with no indication of how many performed the literature review or if a mediator was involved in the final decision making on what papers would be reviewed.Results Excessive consumption of alcohol, history of tobacco use, an ageing population, and comorbidities such as cardiopulmonary issues are substantial risk factors for episodes of unfavourable respiratory outcomes. The risk of these outcomes is increased by some of the toxic effects of treatments such as chemotherapy or radiotherapy.Conclusions The COVID-19 outbreak has a potentially disproportionate impact on the cohort of head and neck cancer patients, and the respiratory effects this has on these patients may increase morbidity and mortality. It is important to include alcohol and smoking cessation, along with good oral hygiene instruction in the care of these patients.

摘要

数据来源

本综述未明确所选的不同数据库,也未说明其检索方式。所使用的研究来自1975年至2020年。

研究选择

作者进行了一项范围综述,使用了1975年至2020年的84项研究。其中大多数研究来自2019 - 2020年新冠疫情爆发之前。这表明该主题缺乏证据,也说明了为什么进行的是范围综述而非系统综述。所审查的研究主要是队列研究和病例研究。关于既往治疗结果,纳入了一些系统综述,但同样,此次疫情的新特性意味着,很大程度上,可供审查的只有队列研究或病例研究。

数据提取与综合

有十位作者,未表明有多少人进行了文献综述,也未说明是否有调解人参与最终关于哪些论文将被审查的决策。

结果

过量饮酒、吸烟史、人口老龄化以及心肺问题等合并症是不良呼吸结局发作的重要风险因素。化疗或放疗等治疗的一些毒性作用会增加这些结局的风险。

结论

新冠疫情对头颈部癌症患者群体可能产生不成比例的影响,其对这些患者的呼吸影响可能会增加发病率和死亡率。在这些患者的护理中,纳入戒酒和戒烟以及良好的口腔卫生指导很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/526b/7317258/b43122d6263b/41432_2020_91_Fig1_HTML.jpg

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