Department of Pathology, University of Health Sciences School of Medicine, İstanbul Training and Research Hospital, İstanbul, Turkey.
Clinic of Pathology, Şırnak State Hospital, Şırnak, Turkey.
Turk J Gastroenterol. 2020 Mar;31(3):205-210. doi: 10.5152/tjg.2020.18850.
BACKGROUND/AIMS: The association of Epstein-Barr virus (EBV) with gastric malignancies has been proven by many studies in the literature. However, information about EBV-associated inflammation/gastritis remains limited. The aim of this study is to establish the prevalence of latent EBV infection in patients with chronic gastritis without H. pylori infection.
In this study, 119 patients with gastritis without H. pylori infection were included. Furthermore, 28 patients with H. pylori gastritis were included in the study as a control group. Chromogenic in situ hybridization (EBV-encoded RNA) and immunohistochemistry (LMP-1 antibody) were performed in all 147 cases. The prevalence of EBV and its relationship with age, sex, the affected part of the stomach, the density of inflammation, inflammatory activity, intestinal metaplasia, and atrophy were analyzed.
In this study, 14 cases showed positive immunostaining for EBV. EBV positivity was seen mostly in the lymphoid tissue (13 cases), but it was also detected at the gastric epithelium (7 cases). The mean age of the patients was 44 years, which was slightly younger than that of the EBV-negative cases (48 years). The inflammation density was higher in EBV-positive cases than the EBV-negative gastritis cases (p=0.002). Intestinal metaplasia was detected in 7% of the cases. EBV-positive cases had a higher incidence of atrophy without intestinal metaplasia (21% vs 3.8% without EBV).
EBV was detected in 12% of the cases with gastritis without H. pylori infection. Endoscopic follow-up may be appropriate for patients with gastritis, who have atrophy without intestinal metaplasia and are H. pylori negative but EBV positive.
背景/目的：许多文献研究已经证明了 Epstein-Barr 病毒（EBV）与胃恶性肿瘤之间的关联。然而，关于 EBV 相关炎症/胃炎的信息仍然有限。本研究旨在确定无幽门螺杆菌感染的慢性胃炎患者中潜伏 EBV 感染的流行率。
本研究纳入了 119 例无幽门螺杆菌感染的胃炎患者。此外，作为对照组，研究中还纳入了 28 例幽门螺杆菌胃炎患者。所有 147 例患者均进行了显色原位杂交（EBV 编码 RNA）和免疫组化（LMP-1 抗体）。分析了 EBV 的流行率及其与年龄、性别、胃受累部位、炎症密度、炎症活性、肠化生和萎缩的关系。
本研究中，有 14 例病例 EBV 免疫染色阳性。EBV 阳性主要见于淋巴组织（13 例），但也在胃上皮中检测到（7 例）。患者的平均年龄为 44 岁，略低于 EBV 阴性病例（48 岁）。EBV 阳性病例的炎症密度高于 EBV 阴性胃炎病例（p=0.002）。肠化生在 7%的病例中检测到。无肠化生的 EBV 阳性病例更易发生萎缩（21%比无 EBV 的病例 3.8%）。
在无幽门螺杆菌感染的胃炎病例中，检测到 12%的病例存在 EBV。对于无肠化生且 EBV 阳性而无幽门螺杆菌感染的胃炎患者，可能需要进行内镜随访。
