Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
Institute of Ecology, Key Laboratory of Agrometeorology of Jiangsu Province, School of Applied Meteorology, Nanjing University of Information Science and Technology, Nanjing Jiangsu, China.
Environ Res. 2020 Jul;186:109559. doi: 10.1016/j.envres.2020.109559. Epub 2020 Apr 21.
The hormetic, biphasic dose response, is highly generalizable, being independent of biological model, level of biological organization, endpoint, inducing agent, and mechanisms. It plays a significant role in mediating both constitutive and adaptable responses in essentially all cells and organisms. The present paper provides both a historical overview of the origin of the hormetic concept in the biological and biomedical sciences, and its potential role in ecology, evolution, and development. These integrative findings provide a broad scientific framework to better understand complex evolutionary-based selection strategies, affecting survival, lifespan, fecundity, learning/memory, tissue repair, reproduction and cooperation, and developmental processes, and offering resilience in the presence of numerous challenges.
双相剂量反应的适应性反应具有高度的普遍性，不受生物模型、生物组织层次、终点、诱导剂和机制的影响。它在介导所有细胞和生物体的组成性和适应性反应中起着重要作用。本文提供了生物学和生物医学科学中激素概念的起源的历史概述，以及它在生态学、进化和发展中的潜在作用。这些综合发现为更好地理解基于进化的复杂选择策略提供了一个广泛的科学框架，这些策略影响着生存、寿命、繁殖力、学习/记忆、组织修复、生殖和合作以及发育过程，并在面临众多挑战时提供了恢复能力。
