Calabrese Edward J
Department of Public Health, Environmental Health Sciences, Morrill I, N344; Amherst, MA 01003 USA.
Microb Cell. 2014 Apr 23;1(5):145-149. doi: 10.15698/mic2014.05.145.
This paper assesses the hormesis dose response concept, including its historical foundations, frequency, generality, quantitative features, mechanistic basis and biomedical, pharmaceutical and environmental health implications. The hormetic dose response is highly generalizable, being independent of biology model (i.e. common from plants to humans), level of biological organization (i.e. cell, organ and organism), endpoint, inducing agent and mechanism, providing the first general and quantitative description of plasticity. The hormetic dose response describes the limits to which integrative endpoints (e.g. cell proliferation, cell migration, growth patterns, tissue repair, aging processes, complex behaviors such as anxiety, learning, memory, and stress, preconditioning responses, and numerous adaptive responses) can be modulated (i.e., enhanced or diminished) by pharmaceutical, chemical and physical means. Thus, the hormesis concept is a fundamental concept in biology with a wide range of biological implications and biomedical applications.
本文评估了兴奋效应剂量反应概念，包括其历史基础、出现频率、普遍性、定量特征、作用机制基础以及对生物医学、制药和环境卫生的影响。兴奋效应剂量反应具有高度的普遍性，独立于生物学模型（即从植物到人类普遍存在）、生物组织水平（即细胞、器官和生物体）、终点指标、诱导剂和作用机制，首次对可塑性进行了一般性和定量描述。兴奋效应剂量反应描述了通过药物、化学和物理手段对综合终点指标（如细胞增殖、细胞迁移、生长模式、组织修复、衰老过程、诸如焦虑、学习、记忆和应激等复杂行为、预处理反应以及众多适应性反应）进行调节（即增强或减弱）的限度。因此，兴奋效应概念是生物学中的一个基本概念，具有广泛的生物学意义和生物医学应用。
