Martin R J, Nearman H S, Katona P G, Klaus M H
J Pediatr. 1977 Jun;90(6):976-81. doi: 10.1016/s0022-3476(77)80575-1.
The airway occlusion technique was used to measure the strength of the Hering-Breuer inflation reflex before and during the administration of low pressure CPAP. In five of 12 preterm infants studied in the first two weeks of life, CPAP did not alter the inflation reflex. In the other seven premature infants, shortened rather than lengthened inspiratory efforts were observed on occlusion 32 times of CPAP but only twice on CPAP. In seven term infants at 1 to 2.5 hours of age this shortening was noted only twice in 58 occlusions. In the preterm infants exhibiting short responses, the peak inspiratory pressure generated in response to occlusion rose on CPAP from 3.4 to 7.1 cm H2O (p less than 0.005), while respiratory rate fell from 61 to 49 breaths/minute (p less than 0.025). This data suggests that CPAP enhances these infants' ability to adjust to increased respiratory loads, possibly by the elimination of a Hering-Breuer deflation reflex.
在给予低压持续气道正压通气（CPAP）之前及期间，采用气道阻塞技术测量黑林-布雷尔充气反射的强度。在出生后前两周研究的12例早产儿中，有5例CPAP未改变充气反射。在其他7例早产儿中，CPAP时阻塞32次观察到吸气努力缩短而非延长，而持续气道正压通气时仅2次。在7例1至2.5小时龄的足月儿中，58次阻塞中仅2次观察到这种缩短。在表现出短反应的早产儿中，阻塞时产生的吸气峰压在CPAP时从3.4厘米水柱升至7.1厘米水柱（p<0.005），而呼吸频率从61次/分钟降至49次/分钟（p<0.025）。该数据表明，CPAP可能通过消除黑林-布雷尔呼气反射增强这些婴儿适应增加的呼吸负荷的能力。
