Sambataro Domenico, Sambataro Gianluca, Libra Alessandro, Vignigni Giovanna, Pino Fabio, Fagone Evelina, Fruciano Mary, Gili Elisa, Pignataro Francesca, Del Papa Nicoletta, Vancheri Carlo
Artroreuma S.R.L., Outpatient of Rheumatology associated with the National Health System corso S. Vito 53, 95030 Mascalucia (Catania), Italy.
Department of Clinical and Experimental Medicine, Internal Medicine Unit, Cannizzaro Hospital, University of Catania, via Messina 829, 95100 Catania, Italy.
Diagnostics (Basel). 2020 Apr 25;10(5):253. doi: 10.3390/diagnostics10050253.
Nailfold videocapillaroscopy (NVC) is an easy tool used for the assessment of patients with Raynaud's phenomenon (RP) as possibly associated with systemic sclerosis (SSc). Recent insights have also highlighted its role in the diagnostic assessment of idiopathic inflammatory myopathies (IIMs). The aim of this study is to describe the diagnostic role of NVC in a series of 361 consecutive patients with interstitial lung disease (ILD). All the patients were assessed by clinical pulmonary and rheumatic examinations, blood exams, high-resolution computed tomography and NVC. NVC was considered positive only in the presence of avascular areas or giant capillaries, but also, the presence of bushy capillaries (BCs) was recorded. NVC was positive in 17.7% of ILD patients and in 78.1% of ILD patients associated with a diagnosis of connective tissue disease (CTD). In 25% of SSc-ILD patients, NVC proved necessary for a correct diagnosis. The presence of BCs and/or NVC positivity in ILD patients with normal levels of creatine phosphokinase is associated with amyopathic IIM, regardless the presence of RP. In conclusion, NVC is useful for the diagnostic assessment of incomplete forms of CTD and in amyopathic IIMs. NVC should be considered in the diagnostic assessment of ILD patients regardless of the presence of RP.
甲襞视频毛细血管镜检查（NVC）是一种用于评估可能与系统性硬化症（SSc）相关的雷诺现象（RP）患者的简便工具。近期的研究也凸显了其在特发性炎性肌病（IIM）诊断评估中的作用。本研究旨在描述NVC在361例连续性间质性肺疾病（ILD）患者中的诊断作用。所有患者均接受了临床肺部和风湿科检查、血液检查、高分辨率计算机断层扫描及NVC检查。仅在出现无血管区或巨大毛细血管时，NVC才被视为阳性，同时，还记录了浓密毛细血管（BC）的存在情况。17.7%的ILD患者NVC呈阳性，在诊断为结缔组织病（CTD）的ILD患者中，这一比例为78.1%。在25%的SSc-ILD患者中，NVC被证明对正确诊断至关重要。肌酸磷酸激酶水平正常的ILD患者中，BC的存在和/或NVC阳性与无肌病性IIM相关，无论是否存在RP。总之，NVC对CTD不完全型及无肌病性IIM的诊断评估有用。无论是否存在RP，在ILD患者的诊断评估中均应考虑NVC。
