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泰国传统草药配方Kleeb Bua Daeng对阿尔茨海默病的多靶点作用

Multitarget Activities of Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Against Alzheimer's Disease.

作者信息

Chheng Chantha, Waiwut Pornthip, Plekratoke Kusawadee, Chulikhit Yaowared, Daodee Supawadee, Monthakantirat Orawan, Pitiporn Supaporn, Musigavong Natdanai, Kwankhao Pakakrong, Boonyarat Chantana

机构信息

Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.

Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.

出版信息

Pharmaceuticals (Basel). 2020 Apr 25;13(5):79. doi: 10.3390/ph13050079.

DOI:10.3390/ph13050079
PMID:32344916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7281753/
Abstract

The Kleeb Bua Daeng formula (KBD) is a Thai traditional medicine for brain health promotion. On the basis of the activities of its individual components, the KBD could have good potential for the treatment of Alzheimer's disease (AD). Herein, we investigated the KBD as an AD treatment. The ethanol extracts of KBD and its components, i.e., (NN), fruits (BP), and the aerial part of (CA) exhibited antioxidant activity, as determined by both ABTS and DPPH assays. The Ellman's assay revealed that the KBD, NN, and BP showed an ability to inhibit acetylcholinesterase. The thioflavin T assay indicated that the KBD, NN, BP, and CA inhibited beta-amyloid aggregation. The neuroprotection and Western blot analysis revealed that the KBD reduced HO-induced neuronal cell death by inhibiting the expression of pro-apoptotic factors, i.e., cleaved caspase-9 and -3, p-P65, p-JNK, and p-GSK-3β, as well as by inducing expression of anti-apoptotic factors, i.e., MCl, BCl, and survivin. Furthermore, the KBD could improve scopolamine induced memory deficit in mice. Our results illustrate that the KBD with multimode action has the potential to be employed in AD treatment. Thus, the KBD could be used as an alternative novel choice for the prevention and treatment of patients with AD.

摘要

Kleeb Bua Daeng配方（KBD）是一种用于促进大脑健康的泰国传统药物。基于其各个成分的活性，KBD在治疗阿尔茨海默病（AD）方面可能具有良好的潜力。在此，我们对KBD作为AD治疗药物进行了研究。通过ABTS和DPPH测定法确定，KBD及其成分，即（NN）、果实（BP）和（CA）的地上部分的乙醇提取物具有抗氧化活性。Ellman测定法显示，KBD、NN和BP具有抑制乙酰胆碱酯酶的能力。硫黄素T测定法表明，KBD、NN、BP和CA抑制β-淀粉样蛋白聚集。神经保护和蛋白质印迹分析表明，KBD通过抑制促凋亡因子（即裂解的半胱天冬酶-9和-3、p-P65、p-JNK和p-GSK-3β）的表达，以及诱导抗凋亡因子（即MCl、BCl和生存素）的表达，减少了HO诱导的神经元细胞死亡。此外，KBD可以改善东莨菪碱诱导的小鼠记忆缺陷。我们的结果表明，具有多模式作用的KBD有潜力用于AD治疗。因此，KBD可以作为预防和治疗AD患者的一种新型替代选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c83/7281753/cb241f4f889a/pharmaceuticals-13-00079-g007.jpg
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