REPIC：一个用于探索 N6-甲基腺苷甲基组的数据库。
REPIC: a database for exploring the N-methyladenosine methylome.
机构信息
Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.
Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, 60637, USA.
出版信息
Genome Biol. 2020 Apr 28;21(1):100. doi: 10.1186/s13059-020-02012-4.
The REPIC (RNA EPItranscriptome Collection) database records about 10 million peaks called from publicly available mA-seq and MeRIP-seq data using our unified pipeline. These data were collected from 672 samples of 49 studies, covering 61 cell lines or tissues in 11 organisms. REPIC allows users to query N-methyladenosine (mA) modification sites by specific cell lines or tissue types. In addition, it integrates mA/MeRIP-seq data with 1418 histone ChIP-seq and 118 DNase-seq data tracks from the ENCODE project in a modern genome browser to present a comprehensive atlas of mA methylation sites, histone modification sites, and chromatin accessibility regions. REPIC is accessible at https://repicmod.uchicago.edu/repic.
REPIC（RNA EPItranscriptome 集合）数据库记录了约 1000 万个峰，这些峰是使用我们的统一管道从公开可用的 mA-seq 和 MeRIP-seq 数据中调用的。这些数据来自 49 项研究的 672 个样本，涵盖了 11 种生物的 61 种细胞系或组织。REPIC 允许用户通过特定的细胞系或组织类型查询 N6-甲基腺嘌呤（mA）修饰位点。此外，它将 mA/MeRIP-seq 数据与 ENCODE 项目中的 1418 个组蛋白 ChIP-seq 和 118 个 DNase-seq 数据轨道整合到一个现代基因组浏览器中，呈现出 mA 甲基化位点、组蛋白修饰位点和染色质可及性区域的综合图谱。REPIC 可在 https://repicmod.uchicago.edu/repic 上访问。
Zotero 插件