[Effect of hydrocortisone on the metabolic indices of hexosamine-containing biopolymers in the stomach].

The experimental findings showed that hydrocortisone effect on metabolism of hexosamine-containing biopolymers of the stomach was dose-dependent. When administered in a small dose (0.2 mg/kg body weight) it increased the activity of biosynthesis of hexosamines, which are necessary for the formation of hexosamine-containing biopolymers, and also increased the total content in the gastric wall of biopolymers, glycosaminoglycans and glycoproteins soluble in perchloric acid. Administration of a large dose of the hormone (50 mg/kg) produced opposite changes in the studied tissue. In patients with peptic ulcer of the stomach and duodenum, exacerbation of which occurred against the background of stress-induced hypercorticosteroidemia, there was observed a decrease of glycosaminoglycan content in the gastric juice and mucosa. A decrease of hexosamine content in glycoproteins was noted.