Escuela Nacional de Ciencias Bilógicas, Instituto Politécnico Nacional, Mexico City, Mexico; Department of Molecular Microbiology, Washington University School of Medicine in St Louis, St. Louis, MO, United States; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Department of Molecular Microbiology, Washington University School of Medicine in St Louis, St. Louis, MO, United States.
Cytokine Growth Factor Rev. 2020 Jun;53:53-62. doi: 10.1016/j.cytogfr.2020.04.004. Epub 2020 Apr 23.
C-X-C motif chemokine 17 (CXCL-17) is a novel chemokine that plays a functional role maintaining homeostasis at distinct mucosal barriers, including regulation of myeloid-cell recruitment, angiogenesis, and control of microorganisms. Particularly, CXCL17 is produced along the epithelium of the airways both at steady state and under inflammatory conditions. While increased CXCL17 expression is associated with disease progression in pulmonary fibrosis, asthma, and lung/hepatic cancer, it is thought to play a protective role in pancreatic cancer, autoimmune encephalomyelitis and viral infections. Thus, there is emerging evidence pointing to both a harmful and protective role for CXCL17 in human health and disease, with therapeutic potential for translational applications. In this review, we provide an overview of the discovery, characteristics and functions of CXCL17 emphasizing its clinical potential in respiratory disorders.
C-X-C 基序趋化因子 17（CXCL-17）是一种新型趋化因子，在维持不同黏膜屏障的内稳态方面发挥功能作用，包括调节髓样细胞募集、血管生成和控制微生物。特别是，CXCL17 在气道的上皮细胞中在稳定状态和炎症条件下都有产生。虽然在肺纤维化、哮喘和肺/肝癌症中，CXCL17 的表达增加与疾病进展相关，但它被认为在胰腺癌、自身免疫性脑脊髓炎和病毒感染中发挥保护作用。因此，有越来越多的证据表明 CXCL17 在人类健康和疾病中具有既有害又有益的作用，具有转化应用的治疗潜力。在这篇综述中，我们概述了 CXCL17 的发现、特性和功能，强调了其在呼吸障碍中的临床潜力。
