Laboratory for Experimental Anesthesiology, Department of Anesthesiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Curr Opin Crit Care. 2020 Jun;26(3):289-295. doi: 10.1097/MCC.0000000000000719.
To fully exploit the concept of hemodynamic coherence in resuscitating critically ill one should preferably take into account information about the state of parenchymal cells. Monitoring of mitochondrial oxygen tension (mitoPO2) has emerged as a clinical means to assess information of oxygen delivery and oxygen utilization at the mitochondrial level. This review will outline the basics of the technique, summarize its development and describe the rationale of measuring oxygen at the mitochondrial level.
Mitochondrial oxygen tension can be measured by means of the protoporphyrin IX-Triplet State Lifetime Technique (PpIX-TSLT). After validation and use in preclinical animal models, the technique has recently become commercially available in the form of a clinical measuring system. This system has now been used in a number of healthy volunteer studies and is currently being evaluated in studies in perioperative and intensive care patients in several European university hospitals.
PpIX-TSLT is a noninvasive and well tolerated method to assess aspects of mitochondrial function at the bedside. It allows doctors to look beyond the macrocirculation and microcirculation and to take the oxygen balance at the cellular level into account in treatment strategies.
为了充分利用血流动力学相干性的概念来复苏危重病患者，最好能考虑到实质细胞状态的信息。监测线粒体氧张力（mitoPO2）已经成为一种评估线粒体水平氧输送和氧利用信息的临床手段。这篇综述将概述该技术的基础，总结其发展，并描述测量线粒体水平氧的基本原理。
线粒体氧张力可以通过原卟啉 IX-三重态寿命技术（PpIX-TSLT）来测量。经过验证并在临床前动物模型中使用后，该技术最近已以临床测量系统的形式商业化。该系统现已在多项健康志愿者研究中使用，并正在几家欧洲大学医院的围手术期和重症监护患者研究中进行评估。
PpIX-TSLT 是一种非侵入性且耐受性良好的方法，可在床边评估线粒体功能的各个方面。它使医生能够超越大循环和微循环，并在治疗策略中考虑细胞水平的氧平衡。
