Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Trends Cancer. 2020 May;6(5):407-418. doi: 10.1016/j.trecan.2020.02.006. Epub 2020 Mar 13.
Pediatric cancer is a leading cause of death in children and adolescents. Improvements in pediatric cancer treatment that include the alleviation of long-term adverse effects require a deeper understanding of the genetic, epigenetic, and developmental factors driving these cancers. Here, we review how the unique attributes of the zebrafish model system in embryology, imaging, and scalability have been used to identify new mechanisms of tumor initiation, progression, and relapse and for drug discovery. We focus on zebrafish models of leukemias, neural tumors and sarcomas - the most common and difficult childhood cancers to treat.
儿科癌症是儿童和青少年死亡的主要原因。为了改善儿科癌症治疗，包括缓解长期的不良反应，我们需要更深入地了解导致这些癌症的遗传、表观遗传和发育因素。在这里，我们回顾了斑马鱼模型系统在胚胎学、成像和可扩展性方面的独特属性如何被用于鉴定肿瘤起始、进展和复发的新机制，并用于药物发现。我们重点介绍了斑马鱼白血病、神经肿瘤和肉瘤模型，这些是最常见和最难治疗的儿童癌症。
