Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China; International and Inter University Centre for Nanoscience and Nanotechnology,Mahatma Gandhi University, Kottayam 686 560, Kerala, India.
Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713 Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713, Doha, Qatar.
Int J Biol Macromol. 2020 Aug 15;157:350-358. doi: 10.1016/j.ijbiomac.2020.04.175. Epub 2020 Apr 26.
Curcumin loaded lipid-polymer hybrid nanoparticles dispersions were fabricated from carboxymethylcellulose, stearic acid, polyethylene glycol and sesame oil using emulsion solvent evaporation method for their possible application as edible coatings for fresh vegetables and fruits. They were characterized by FTIR and TEM analysis. In addition, anti-bacterial, blood compatibility, cytotoxicity and anticancer studies were also carried out. The prepared nanodispersions showed excellent mixed nanostructured morphology with an average size of 94.96 nm. The hybrid nanodispersions showed excellent blood compatibility, non-toxicity and antitumor activity. The synthesized nanoparticle dispersion was employed as an edible coating solution for fresh apples and tomatoes. The hybrid system coated vegetables and fruits shows minimal weight loss after 15 days of storage. Hence, the formulated hybrid nanostructures of CMC are promising as edible coating solution, in addition to possessing the properties to fight cancer.
姜黄素负载的脂质-聚合物杂化纳米粒子分散体是由羧甲基纤维素、硬脂酸、聚乙二醇和芝麻油通过乳液溶剂蒸发法制备的，用于将其作为新鲜蔬菜和水果的可食用涂层的可能应用。它们通过傅里叶变换红外光谱（FTIR）和透射电子显微镜（TEM）分析进行了表征。此外，还进行了抗菌、血液相容性、细胞毒性和抗癌研究。所制备的纳米分散体显示出具有平均尺寸为 94.96nm 的极好的混合纳米结构形态。杂化纳米分散体显示出极好的血液相容性、无毒和抗肿瘤活性。合成的纳米粒子分散体被用作新鲜苹果和西红柿的可食用涂层溶液。在 15 天的储存后，杂化系统涂覆的蔬菜和水果的重量损失最小。因此，除了具有抗癌特性外，所制备的 CMC 杂化纳米结构有望成为可食用的涂层溶液。
