Faculdade de Ciências e Tecnologia, Universidade de Cabo Verde, Praia, Santiago, Cabo Verde.
Department of Genetics and Genome Biology, University of Leicester, Leicester, UK; Department of Molecular Biotechnology and Microbiology, Gdansk University of Technology, Gdansk, Poland.
J Glob Antimicrob Resist. 2020 Sep;22:483-487. doi: 10.1016/j.jgar.2020.04.002. Epub 2020 Apr 27.
Data on baseline drug resistance important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates available for the African archipelago of Cabo Verde.
We performed a retrospective analysis over years (2013-17) of the drug susceptibility profiles of clinical isolates in the two main hospitals of Cabo Verde. For Escherichia coli and Staphylococcus aureus, representing 47% and 26% of all clinical isolates, the antimicrobial drug resistance profile was reported for six representative drugs.
For E. coli we detected an increase in resistance to ampicillin, amoxicillin/clavulanic acid, ceftriaxone, ciprofloxacin and trimethoprim-and for S. aureus to methicillin, erythromycin and trimethoprim-sulfamethoxazole. This increase in both the most commonly isolated bacterial pathogens is alarm as it might compromise empirical treatment in a setting with limited access to laboratory testing.
When compared to the published low resistance rates in carriage isolates, the more alarming situation in clinical isolates for S. aureus might encourage antimicrobial stewardship programs to reduce in hospital settings, possibly as part of the Cabo Verdean national plan against antimicrobial drug resistance.
了解基线耐药数据对于未来抗菌药物管理计划至关重要。迄今为止，尚无关于佛得角非洲群岛临床分离株的抗菌药物耐药性的数据。
我们对佛得角两家主要医院的临床分离株进行了多年（2013-2017 年）的药物敏感性分析。对于代表所有临床分离株的 47%的大肠埃希菌和 26%的金黄色葡萄球菌，报告了 6 种代表性药物的抗菌药物耐药谱。
我们发现大肠埃希菌对氨苄西林、阿莫西林/克拉维酸、头孢曲松、环丙沙星和复方磺胺甲噁唑的耐药性增加，而金黄色葡萄球菌对甲氧西林、红霉素和复方磺胺甲噁唑的耐药性增加。这两种最常见的分离细菌病原体的耐药性增加令人担忧，因为在实验室检测有限的情况下，这可能会影响经验性治疗。
与携带分离株中公布的低耐药率相比，金黄色葡萄球菌临床分离株的情况更为严峻，这可能促使抗菌药物管理计划在医院环境中减少使用，可能作为佛得角国家对抗抗菌药物耐药性计划的一部分。
