Jasielec Jerzy J, Filipek Robert, Dołowy Krzysztof, Lewenstam Andrzej
Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland.
Department of Physics and Biophysics, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warszawa, Poland.
Membranes (Basel). 2020 Apr 27;10(5):81. doi: 10.3390/membranes10050081.
In the mitochondrial matrix there are insoluble, osmotically inactive complexes that maintain constant pH and calcium concentration. In the present paper we examine the properties of insoluble calcium and magnesium salts, namely phosphates, carbonates and polyphosphates which might play this role. We find that non-stoichiometric, magnesium-rich carbonated apatite, with very low crystallinity, precipitates in the matrix under physiological conditions. Precipitated salt acts as pH buffer, and hence can contribute in maintaining ATP production in ischemic conditions, delaying irreversible damages to heart and brain cells after stroke.
在线粒体基质中存在不溶性、无渗透活性的复合物，它们能维持恒定的pH值和钙浓度。在本文中，我们研究了可能发挥这一作用的不溶性钙盐和镁盐，即磷酸盐、碳酸盐和多聚磷酸盐的性质。我们发现，在生理条件下，结晶度极低的非化学计量富镁碳酸磷灰石会在基质中沉淀。沉淀的盐充当pH缓冲剂，因此有助于在缺血条件下维持ATP的产生，延迟中风后心脏和脑细胞的不可逆损伤。
