Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Japan.
Department of Pharmacy, Ube-Kohsan Central Hospital, Japan.
Jpn J Infect Dis. 2020 Sep 24;73(5):363-365. doi: 10.7883/yoken.JJID.2019.534. Epub 2020 Apr 30.
In this study, we investigated four clinical cases of microbial contamination of in-use intravenous infusion fluid, detected by measuring "Adenosine triphosphate (ATP) + adenosine monophosphate (AMP)" ("ATP+AMP") levels. High "ATP+AMP" values correlate with microbial contamination, and by utilizing these values as indicator for microbial contamination possibility, we were able to rapidly detect the contamination and recommend replacement of catheters and administration sets. In three out of four cases, changing the infusion fluid led to improvement in the condition of the patients. "ATP+AMP" levels can be used to confirm microbial contamination of in-use intravenous infusion fluids, as it is fast (several minites) and convenient to measure them.
在这项研究中，我们通过测量“三磷酸腺苷（ATP）+一磷酸腺苷（AMP）”（“ATP+AMP”）水平，调查了四例临床中发现的在使用静脉输液中微生物污染的案例。高“ATP+AMP”值与微生物污染相关，并且通过将这些值用作微生物污染可能性的指标，我们能够快速检测到污染并建议更换导管和输液器。在四个案例中有三个，更换输液液体会导致患者病情改善。“ATP+AMP”水平可用于确认在使用的静脉输液中的微生物污染，因为测量它们非常快速（几分钟）和方便。
