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墨西哥菌株的全基因组测序：牛无浆体病病原体的一种研究方法

Whole-Genome Sequencing of Mexican Strains of : An Approach to the Causal Agent of Bovine Anaplasmosis.

作者信息

Martínez-Ocampo Fernando, Quiroz-Castañeda Rosa Estela, Amaro-Estrada Itzel, Dantán-González Edgar, de la Torre Jesús Francisco Preciado, Rodríguez-Camarillo Sergio

机构信息

Laboratorio de Estudios Ecogenómicos, Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, C.P. 62209 Cuernavaca, Morelos, Mexico.

Unidad de Anaplasmosis, Centro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad, INIFAP, C.P. 62574 Jiutepec, Morelos, Mexico.

出版信息

Int J Genomics. 2020 Apr 14;2020:5902029. doi: 10.1155/2020/5902029. eCollection 2020.

DOI:10.1155/2020/5902029
PMID:32351981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7178543/
Abstract

is the main etiologic agent of bovine anaplasmosis, and it is extensively distributed worldwide. We have previously reported the first genome sequence of a Mexican strain of (Mex-01-001-01). In this work, we report the genomic analysis of one strain from Hidalgo (MEX-14-010-01), one from Morelos (MEX-17-017-01), and two strains from Veracruz (MEX-30-184-02 and MEX-30-193-01). We found that the genome average size is 1.16-1.17 Mbp with a GC content close to 49.80%. The genomic comparison reveals that most of the genomes are highly conserved and the phylogeny showed that Mexican strains cluster with Brazilian strains. The genomic information contained in the four draft genomes of from Mexico will contribute to understanding the molecular landscape of this pathogen.

摘要

是牛无浆体病的主要病原体，在全球广泛分布。我们之前报道过墨西哥菌株（Mex-01-001-01）的首个基因组序列。在这项工作中，我们报告了来自伊达尔戈州的一个菌株（MEX-14-010-01）、来自莫雷洛斯州的一个菌株（MEX-17-017-01）以及来自韦拉克鲁斯州的两个菌株（MEX-30-184-02和MEX-30-193-01）的基因组分析。我们发现基因组平均大小为1.16 - 1.17 Mbp，GC含量接近49.80%。基因组比较显示，大多数基因组高度保守，系统发育分析表明墨西哥菌株与巴西菌株聚类。来自墨西哥的这四个 基因组草图中包含的基因组信息将有助于了解这种病原体的分子格局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583f/7178543/9aa697799a54/IJG2020-5902029.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583f/7178543/5db6457ea9b1/IJG2020-5902029.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583f/7178543/c95ad5682e9e/IJG2020-5902029.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583f/7178543/9aa697799a54/IJG2020-5902029.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583f/7178543/5db6457ea9b1/IJG2020-5902029.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583f/7178543/c95ad5682e9e/IJG2020-5902029.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583f/7178543/9aa697799a54/IJG2020-5902029.003.jpg

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