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Gas6在晚期乳腺癌中的表达降低。

Gas6 expression is reduced in advanced breast cancers.

作者信息

Ibrahim Ayman M, Gray Zane, Gomes Angelica M, Myers Leann, Behbod Fariba, Machado Heather L

机构信息

1Department of Biochemistry and Molecular Biology, Tulane Cancer Center, Tulane School of Medicine, New Orleans, LA USA.

2Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt.

出版信息

NPJ Precis Oncol. 2020 Apr 24;4:9. doi: 10.1038/s41698-020-0116-z. eCollection 2020.

DOI:10.1038/s41698-020-0116-z
PMID:32352034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7181799/
Abstract

Growth arrest-specific gene 6 (Gas6) is a cytokine that binds to receptor tyrosine kinases Tyro3, Axl, and Mer. Numerous studies have suggested that macrophage-derived Gas6 interacts with Axl to promote cancer progression, and Axl has been associated with poor clinical outcome. However, the expression and relevance of Gas6 in human breast cancer patients has not been studied. Analysis of tissue microarrays showed that Gas6 was highly expressed in ductal carcinoma in situ (DCIS) but markedly decreased in invasive breast cancer. Gas6 and Axl were weakly correlated, suggesting that their functions may not exclusively rely on each other. Analyses of publicly available databases showed significantly improved overall and relapse-free survival in patients with high Gas6 mRNA, particularly in luminal A breast cancers. These findings indicate that tumor-derived Gas6 is not overexpressed in invasive breast cancer, and may not be a negative prognostic factor in human breast cancer.

摘要

生长停滞特异性基因6（Gas6）是一种细胞因子，可与受体酪氨酸激酶Tyro3、Axl和Mer结合。大量研究表明，巨噬细胞衍生的Gas6与Axl相互作用以促进癌症进展，并且Axl与不良临床结果相关。然而，尚未对Gas6在人类乳腺癌患者中的表达及相关性进行研究。组织微阵列分析显示，Gas6在原位导管癌（DCIS）中高表达，但在浸润性乳腺癌中明显降低。Gas6和Axl呈弱相关性，表明它们的功能可能并非完全相互依赖。对公开数据库的分析显示，Gas6 mRNA水平高的患者总生存期和无复发生存期显著改善，尤其是在腔面A型乳腺癌中。这些发现表明，肿瘤衍生的Gas6在浸润性乳腺癌中并未过度表达，可能不是人类乳腺癌的负性预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/5a006610065e/41698_2020_116_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/6fe7f0178de3/41698_2020_116_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/072f1525abb6/41698_2020_116_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/c53e089dc26a/41698_2020_116_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/5a006610065e/41698_2020_116_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/6fe7f0178de3/41698_2020_116_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/072f1525abb6/41698_2020_116_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/c53e089dc26a/41698_2020_116_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be6/7181799/5a006610065e/41698_2020_116_Fig4_HTML.jpg

相似文献

[1]
Gas6 expression is reduced in advanced breast cancers.

NPJ Precis Oncol. 2020-4-24

[2]
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[3]
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J Comp Neurol. 2000-9-18

[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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Oncotarget. 2016-8-30

[10]
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Clin Cancer Res. 2009-7-15

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[2]
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[3]
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[4]
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[5]
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[6]
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Cancers (Basel). 2022-1-18

[7]
Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling.

Clin Exp Metastasis. 2021-6

[8]
AXL Receptor in Breast Cancer: Molecular Involvement and Therapeutic Limitations.

Int J Mol Sci. 2020-11-10

[9]
Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion.

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本文引用的文献

[1]
Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis.

Oncotarget. 2019-12-17

[2]
Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance.

Oncogene. 2019-4-1

[3]
Gas6 is dispensable for pubertal mammary gland development.

PLoS One. 2018-12-11

[4]
Stromal Gas6 promotes the progression of premalignant mammary cells.

Oncogene. 2018-12-7

[5]
Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment.

Breast Cancer Res. 2018-10-1

[6]
Fibulin-2 is required for basement membrane integrity of mammary epithelium.

Sci Rep. 2018-9-20

[7]
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Cell Rep. 2018-5-1

[8]
Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma.

Cancer Res. 2018-3-12

[9]
Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6.

Front Immunol. 2017-11-10

[10]
Molecular Subtypes and Local-Regional Control of Breast Cancer.

Surg Oncol Clin N Am. 2018-1

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