Jeannin J F, Lagadec P, Pelletier H, Reisser D, Olsson N O, Chihara G, Martin F
I.N.S.E.R.M. U.252, Faculty of Medicine, Dijon, France.
Int J Immunopharmacol. 1988;10(7):855-61. doi: 10.1016/0192-0561(88)90010-0.
Lentinan has been tested in a model of colon cancer in rats. Peritoneal carcinomatoses were induced in BDIX rats by i.p. injections of syngeneic cells isolated from a colon carcinoma, and established in a permanent cell line. The treatment consisted of five i.p. injections, 2 days apart, of 2 mg lentinan/kg at a concentration of 200 micrograms/ml. This was started on day 14 after tumor cell injection, when the rats bore numerous nodules of 1-5 mm. Lentinan significantly inhibited the growth of carcinomatoses. Eleven out of the 20 rats treated with the best lentinan therapy were tumor free at autopsy on day 42. Lentinan significantly increased the life span of carcinomatous rats. The half life following tumor cell injection was 42 days in the control and 70 days in the treated group. Four out of 10 treated rats were still alive on day 210. They were tumor free at autopsy, whereas all the controls died between the 40th and the 70th day. The effectiveness of lentinan was dependent on the number and frequency of the injections. A dose effect was obtained and a strong influence of the concentration was shown.
香菇多糖已在大鼠结肠癌模型中进行了测试。通过腹腔注射从结肠癌分离的同基因细胞，在BDIX大鼠中诱导腹膜癌转移，并建立了永久细胞系。治疗方案为以200微克/毫升的浓度，每2天腹腔注射一次2毫克/千克的香菇多糖，共注射5次。该治疗在肿瘤细胞注射后第14天开始，此时大鼠身上出现了许多1 - 5毫米的结节。香菇多糖显著抑制了癌转移的生长。接受最佳香菇多糖治疗的20只大鼠中，有11只在第42天尸检时无肿瘤。香菇多糖显著延长了患癌大鼠的寿命。肿瘤细胞注射后的半衰期在对照组为42天，在治疗组为70天。10只接受治疗的大鼠中有4只在第210天仍存活。它们在尸检时无肿瘤，而所有对照组大鼠在第40天至第70天之间死亡。香菇多糖的有效性取决于注射的次数和频率。获得了剂量效应，并显示出浓度的强烈影响。
