Department of Public Health, Laboratory for Mother and Child Health, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Academic Division of Child Health, University of Nottingham School of Medicine, Derby DE22 3DT, UK.
Int J Environ Res Public Health. 2020 Apr 28;17(9):3071. doi: 10.3390/ijerph17093071.
Many birth cohorts have been carried out. We performed a review of European birth cohorts to see the countries involved, provide a panorama of the current research topics and design, and, more generally, provide input for those creating collaborations and laying out guidelines aimed at unifying cohort methodologies to enable data merging and maximize knowledge acquisition. We searched PubMed and Embase for articles referring to longitudinal, prospective European birth cohorts and searched online cohort inventories. We found references to 111 birth cohorts, 45 of which began enrolment at birth. These cohorts began between 1921 and 2015 and represented 19 countries, with varying sample sizes (236 to 21,000 children). As of 5 January 2020, were still recruiting. The main areas addressed were allergic diseases (14 cohorts) and environmental exposure (f12 cohorts) and most cohorts were publicly funded. Given the large costs of running cohorts and the importance of long follow-up periods in identifying the risk factors for disorders thought to have a perinatal/early life etiology, current cohorts must be designed to answer research questions considering several aspects, from genetic ones to psychological, social, and environmental ones. Furthermore, universally recognized methodological aspects are needed to permit the comparison and merging of cohort data.
已经进行了许多出生队列研究。我们对欧洲的出生队列进行了综述，以了解所涉及的国家，提供当前研究主题和设计的全景，并更普遍地为那些正在创建合作关系和制定旨在统一队列方法学的指导方针的人提供信息，以实现数据合并并最大限度地获取知识。我们在 PubMed 和 Embase 上搜索了提到纵向、前瞻性欧洲出生队列的文章，并在在线队列目录中进行了搜索。我们找到了 111 个出生队列的参考文献，其中 45 个队列在出生时就开始招募。这些队列的起始时间从 1921 年到 2015 年不等，代表了 19 个国家，样本量大小不一（236 至 21000 名儿童）。截至 2020 年 1 月 5 日，仍在招募参与者。主要研究领域是过敏疾病（14 个队列）和环境暴露（f12 个队列），大多数队列由公共资金资助。鉴于运行队列的成本高昂，以及在确定被认为具有围产期/生命早期病因的疾病的危险因素方面需要长期随访期，当前的队列必须设计为考虑从遗传因素到心理、社会和环境因素等几个方面来回答研究问题。此外，还需要普遍认可的方法学方面，以允许比较和合并队列数据。
