基于知识的容积调强弧形治疗计划在乳腺癌术后放疗中的剂量-体积直方图分析。
Dose-volume Histogram Analysis of Knowledge-based Volumetric-modulated Arc Therapy Planning in Postoperative Breast Cancer Irradiation.
机构信息
Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka, Japan
Department of Radiation Oncology, Kindai University Faculty of Medicine, Osaka, Japan.
出版信息
In Vivo. 2020 May-Jun;34(3):1095-1101. doi: 10.21873/invivo.11880.
Abstract
BACKGROUND/AIM: We evaluated the dosimetric profiles of manually generated volumetric-modulated arc therapy (VMAT) plans and performance of a commercial knowledge-based planning system (KBP) in treating breast cancer.
MATERIALS AND METHODS
We defined the manually generated VMAT plan as the manual plan (MP). Twenty MPs were generated for left-sided breast cancer patients who underwent breast-conserving surgery and used to develop a KBP training set. The other five patients were used for validation. The dosimetric parameters among MPs, tangential irradiation plans (TPs), and KBP-VMAT plans (KBP-Ps) were compared.
RESULTS
D and homogeneity of the planning target volume (PTV) were significantly higher and greater in MPs and KBP-Ps than in TPs. Lung V, V The Dmean for the left anterior descending artery was lower in MPs and KBP-Ps than in TPs. KBP could save time in generating VMAT plans.
CONCLUSION
MPs and KBP-Ps could ensure higher dose uniformity of PTV than TPs. KBP could faster generate comparable MPs for breast cancer.
摘要
背景/目的：我们评估了手动生成的容积旋转调强弧形治疗（VMAT）计划的剂量学曲线，并评估了一种商业基于知识的计划系统（KBP）在治疗乳腺癌方面的性能。
材料与方法
我们将手动生成的 VMAT 计划定义为手动计划（MP）。为接受保乳手术的左侧乳腺癌患者生成了 20 个 MP，并将其用于开发 KBP 训练集。另外 5 名患者用于验证。比较了 MPs、切线照射计划（TP）和 KBP-VMAT 计划（KBP-P）之间的剂量学参数。
结果
与 TP 相比，MPs 和 KBP-Ps 的计划靶区（PTV）D 和均匀性明显更高。左前降支的肺 V、V 5 和 Dmean 明显低于 TP。KBP 可以节省生成 VMAT 计划的时间。
结论
MPs 和 KBP-Ps 可以确保 PTV 的剂量均匀性高于 TP。KBP 可以更快地为乳腺癌生成可比的 MPs。
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