Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
In Vivo. 2020 May-Jun;34(3):1421-1425. doi: 10.21873/invivo.11923.
BACKGROUND/AIM: Elderly patients with a single brain metastasis likely benefit from personalized treatment protocols. To add to treatment personalization, a survival score was generated for these patients.
This retrospective study included 36 elderly patients, each with a single brain metastasis, who received surgery followed by whole-brain irradiation and a radiation boost. Six pre-treatment characteristics were evaluated regarding survival, namely age, gender, Karnofsky performance score (KPS), type of primary tumor, non-cerebral metastasis and interval from diagnosis of the neoplasm until surgery.
When applying the Cox regression model, KPS (p=0.005) and tumor type (p=0.018) were significant and incorporated in the score. Based on 12-month survival probabilities, three groups of 6-9 (n=5), 10-11 (n=15) and 14-19 points (n=16) were formed, with 12-month survival rates of 0%, 33% and 100%, respectively (p<0.0001).
A survival score was generated specifically for elderly patients with a single brain metastasis that can improve personalization of their treatment.
背景/目的：对于单个脑转移的老年患者，可能会从个性化的治疗方案中受益。为了进一步实现治疗的个体化，我们为这些患者生成了一个生存评分。
本回顾性研究纳入了 36 名接受手术切除联合全脑放疗和局部推量放疗的单个脑转移的老年患者。评估了 6 项治疗前特征与生存的相关性，分别是年龄、性别、卡氏功能状态评分（KPS）、原发肿瘤类型、非脑部转移灶和从肿瘤诊断到手术的时间间隔。
应用 Cox 回归模型后，KPS（p=0.005）和肿瘤类型（p=0.018）具有显著意义，并纳入了评分中。根据 12 个月的生存率，将患者分为三组，每组 6-9 分（n=5）、10-11 分（n=15）和 14-19 分（n=16），12 个月的生存率分别为 0%、33%和 100%（p<0.0001）。
我们为单个脑转移的老年患者专门生成了一个生存评分，可以提高治疗的个体化水平。
