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金黄色葡萄球菌TX0117与其β-内酰胺酶缺失衍生物的基因组序列比较显示，伴随着[具体基因1]和[具体基因2]中的突变，阳离子肽抗性增加。

Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in and .

作者信息

Sales Mia Jade, Sakoulas George, Szubin Richard, Palsson Bernhard, Arias Cesar, Singh Kavindra V, Murray Barbara E, Monk Jonathan M

机构信息

Bioengineering Department, University of California San Diego, La Jolla, California, USA.

Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.

出版信息

Microbiol Resour Announc. 2020 Apr 30;9(18):e01515-19. doi: 10.1128/MRA.01515-19.

DOI:10.1128/MRA.01515-19
PMID:32354985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7193940/
Abstract

strain TX0117 is a methicillin-susceptible bacterium with type A beta-lactamase exhibiting a high cefazolin inoculum effect. TX0117 was cured of , yielding TX0117c with increased antimicrobial peptide resistance. The sequencing and genome assembly of TX0117 elucidate six mutations between TX0117 and TX0117c, including truncation and substitution.

摘要

菌株TX0117是一种对甲氧西林敏感的细菌，具有A型β-内酰胺酶，表现出较高的头孢唑林接种物效应。菌株TX0117经治愈后，产生了抗菌肽抗性增加的TX0117c。对TX0117进行测序和基因组组装，阐明了TX0117和TX0117c之间的六个突变，包括截断和替换。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/967f/7193940/ecfd0df2565b/MRA.01515-19-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/967f/7193940/ecfd0df2565b/MRA.01515-19-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/967f/7193940/ecfd0df2565b/MRA.01515-19-f0001.jpg

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Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in and .金黄色葡萄球菌TX0117与其β-内酰胺酶缺失衍生物的基因组序列比较显示，伴随着[具体基因1]和[具体基因2]中的突变，阳离子肽抗性增加。
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